Key steps for effective breast cancer prevention
Despite decades of laboratory, epidemiological and clinical research, breast cancer
incidence continues to rise. Breast cancer remains the leading cancer-related cause of …
incidence continues to rise. Breast cancer remains the leading cancer-related cause of …
[HTML][HTML] Large animal models in regenerative medicine and tissue engineering: to do or not to do
I Ribitsch, PM Baptista, A Lange-Consiglio… - … in Bioengineering and …, 2020 - frontiersin.org
Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an
increasing drive toward clinical translation of breakthrough technologies. However, the …
increasing drive toward clinical translation of breakthrough technologies. However, the …
Detection and interpretation of shared genetic influences on 42 human traits
We performed a scan for genetic variants associated with multiple phenotypes by comparing
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …
New genetic loci link adipose and insulin biology to body fat distribution
D Shungin, TW Winkler, DC Croteau-Chonka… - Nature, 2015 - nature.com
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …
outcomes, independent of overall adiposity. To increase our understanding of the genetic …
Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon
Males and females share many traits that have a common genetic basis; however, selection
on these traits often differs between the sexes, leading to sexual conflict,. Under such sexual …
on these traits often differs between the sexes, leading to sexual conflict,. Under such sexual …
[HTML][HTML] Increased incidence of precocious and accelerated puberty in females during and after the Italian lockdown for the coronavirus 2019 (COVID-19) pandemic
S Stagi, S De Masi, E Bencini, S Losi, S Paci… - Italian Journal of …, 2020 - Springer
Background The timing of puberty in girls is occurring at an increasingly early age. While a
positive family history is recognised as a predisposing factor for early or precocious puberty …
positive family history is recognised as a predisposing factor for early or precocious puberty …
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes …
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes …
The bigger picture of FTO—the first GWAS-identified obesity gene
Single nucleotide polymorphisms (SNPs) that cluster in the first intron of fat mass and
obesity associated (FTO) gene are associated obesity traits in genome-wide association …
obesity associated (FTO) gene are associated obesity traits in genome-wide association …
On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations
A Qasim, M Turcotte, RJ De Souza… - Obesity …, 2018 - Wiley Online Library
Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …
detrimental impact on human health persist through evolutionary time? Numerous …
The mystery of missing heritability: Genetic interactions create phantom heritability
O Zuk, E Hechter, SR Sunyaev… - Proceedings of the …, 2012 - National Acad Sciences
Human genetics has been haunted by the mystery of “missing heritability” of common traits.
Although studies have discovered> 1,200 variants associated with common diseases and …
Although studies have discovered> 1,200 variants associated with common diseases and …