Inhibiting NADPH oxidases to target vascular and other pathologies: an update on recent experimental and clinical studies
AL Sylvester, DX Zhang, S Ran, NS Zinkevich - Biomolecules, 2022 - mdpi.com
Reactive oxygen species (ROS) can be beneficial or harmful in health and disease. While
low levels of ROS serve as signaling molecules to regulate vascular tone and the growth …
low levels of ROS serve as signaling molecules to regulate vascular tone and the growth …
Role of TRPV4 on vascular tone regulation in pathophysiological states
T Matsumoto, K Taguchi, T Kobayashi - European Journal of Pharmacology, 2023 - Elsevier
Vascular tone regulation is a key event in controlling blood flow in the body. Endothelial
cells (ECs) and vascular smooth muscle cells (VSMCs) help regulate the vascular tone …
cells (ECs) and vascular smooth muscle cells (VSMCs) help regulate the vascular tone …
The CaSR/TRPV4 coupling mediates pro‐inflammatory macrophage function
X Chen, W Lu, C Lu, L Zhang, F Xu… - Acta Physiologica, 2023 - Wiley Online Library
Aim Although calcium‐sensing receptor (CaSR) and transient receptor potential vanilloid 4
(TRPV4) channels are functionally expressed on macrophages, it is unclear if they work …
(TRPV4) channels are functionally expressed on macrophages, it is unclear if they work …
[HTML][HTML] LDL-c/HDL-c Ratio and NADPH-Oxidase-2-Derived Oxidative Stress as Main Determinants of Microvascular Endothelial Function in Morbidly Obese Subjects
J Santos, JM La Fuente, A Fernández, P Ruano… - Antioxidants, 2024 - mdpi.com
The identification of obese subjects at higher risk for cardiovascular disease (CVD) is
required. We aimed to characterize determinants of endothelial dysfunction, the initial step to …
required. We aimed to characterize determinants of endothelial dysfunction, the initial step to …
Prolonged L-NAME exposure changes the vasodilator factor from NO to H2O2 in human arterioles in response to A23187
NS Zinkevich, K Drachuk, DX Zhang - Vascular Pharmacology, 2024 - Elsevier
The Ca 2+ ionophore A23187 induces endothelium-dependent and non-receptor-mediated
vasodilation in human adipose arterioles (HAAs). The purpose of this study was to …
vasodilation in human adipose arterioles (HAAs). The purpose of this study was to …
Mechanotransduction in the urothelium: ATP signalling and mechanoreceptors
X Li, J Hu, P Yin, L Liu, Y Chen - Heliyon, 2023 - cell.com
The urothelium, which covers the inner surface of the bladder, is continuously exposed to a
complex physical environment where it is stimulated by, and responds to, a wide range of …
complex physical environment where it is stimulated by, and responds to, a wide range of …