Past, current, and potential treatments for cryptosporidiosis in humans and farm animals: A comprehensive review

SM Khan, WH Witola - Frontiers in cellular and infection microbiology, 2023 - frontiersin.org
The intracellular protozoan parasite of the genus Cryptosporidium is among the leading
causes of waterborne diarrheal disease outbreaks throughout the world. The parasite is …

Emerging treatment options for cryptosporidiosis

MS Love, RKM Choy - Current opinion in infectious diseases, 2021 - journals.lww.com
Several lead compounds with potent activity in animal models and a favorable safety profile
have been identified. A sustained effort will be required to advance at least one to clinical …

Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy

N Caldwell, C Peet, P Miller, BL Colon… - Science Translational …, 2024 - science.org
Cryptosporidiosis is a diarrheal disease caused by infection with Cryptosporidium spp.
parasites and is a leading cause of death in malnourished children worldwide. The only …

Cryptosporidium PI(4)K inhibitor EDI048 is a gut-restricted parasiticidal agent to treat paediatric enteric cryptosporidiosis

UH Manjunatha, SB Lakshminarayana, RS Jumani… - Nature …, 2024 - nature.com
Diarrhoeal disease caused by Cryptosporidium is a major cause of morbidity and mortality in
young and malnourished children from low-and middle-income countries, with no vaccine or …

Identification of potent and orally efficacious phosphodiesterase inhibitors in Cryptosporidium parvum-infected immunocompromised male mice

J Ajiboye, JE Teixeira, M Gasonoo, EB Mattice… - Nature …, 2024 - nature.com
Cryptosporidium parvum and C. hominis are parasites that cause life-threatening diarrhea in
children and immunocompromised people. There is only one approved treatment that is …

Safe and effective treatments are needed for cryptosporidiosis, a truly neglected tropical disease

IH Gilbert, S Vinayak, B Striepen, UH Manjunatha… - BMJ Global …, 2023 - gh.bmj.com
Early childhood cryptosporidiosis causes acute disease and mortality, as well as lasting
malnutrition and developmental delay. However, there are no safe and effective therapeutics …

Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium

JC Hanna, V Corpas-Lopez, S Seizova… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction Cryptosporidiosis is a leading cause of diarrheal-associated morbidity and
mortality, predominantly affecting children under 5 years old in low-and-middle-income …

Protozoan parasites in adult dairy small ruminants and potential predictors for their presence in faecal samples

DT Lianou, KV Arsenopoulos, CK Michael… - Microorganisms, 2022 - mdpi.com
There is a scope to study protozoan infections in adult ewes and does, as these animals can
act as reservoirs of infection for lambs and kids, for which these pathogens are harmful. The …

Combination of inhibitors for two glycolytic enzymes portrays high synergistic efficacy against Cryptosporidium parvum

SM Khan, MR Bajwa, RY Lahar… - Antimicrobial agents and …, 2023 - Am Soc Microbiol
Cryptosporidium is an intracellular protozoan parasite that causes serious enteric disease in
humans and in a wide range of animals worldwide. Despite its high prevalence, no effective …

Medicinal plants as a source of antiparasitics: an overview of experimental studies

S Ranasinghe, A Armson, AJ Lymbery… - Pathogens and global …, 2023 - Taylor & Francis
Despite advances in modern human and veterinary medicine, gastrointestinal (GI) parasitic
infections remain a significant health issue worldwide, mainly in developing countries …