Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

After the first aminoglycoside antibiotic streptomycin being applied in clinical practice in the
mid-1940s, aminoglycoside antibiotics (AGAs) are widely used to treat clinical bacterial …

Bacteriophages must seize control of the host gene expression machinery to replicate. To
bypass bacterial anti-phage defence systems, this host takeover occurs immediately upon …

Long-term infection of the airways of cystic fibrosis patients with Pseudomonas aeruginosa
is often accompanied by a reduction in bacterial growth rate. This reduction has been …

Pseudomonas aeruginosa is a bacterial pathogen associated with a wide range of infections
and utilizes several strategies to establish and maintain infection including biofilm …

(Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter
baumannii, Pseudomonas aeruginosa, and Enterobacter spp) pathogens, has become a …

During translation initiation, initiation factor 2 (IF2) holds initiator transfer RNA (fMet-
tRNAifMet) in a specific orientation in the peptidyl (P) site of the ribosome. Upon subunit …

Genomic studies have indicated that certain bacterial lineages such as the Bacteroidetes
lack Shine-Dalgarno (SD) sequences, and yet with few exceptions ribosomes of these …

In the face of growing antimicrobial resistance, there is an urgent need for the development
of effective strategies to target Pseudomonas aeruginosa. This metabolically versatile …

Leishmania is the causative agent of cutaneous and visceral diseases affecting millions of
individuals worldwide. Pseudouridine (Ψ), the most abundant modification on rRNA …