The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

Assembling non-biological materials (geomaterials) into a proto-organism constitutes a
bridge between nonliving and living matter. In this article we present a simple step-by-step …

Synthetic molecules that can bind with high sequence specificity to a chosen target in a
gene sequence are of major interest in medicinal and biotechnological contexts. They show …

The light-harvesting properties of cationic conjugated polymers are used to sensitize the
emission of a dye on a specific peptide nucleic acid (PNA) sequence for the purpose of …

The binding of a mixed-sequence pentadecamer PNA (peptide nucleic acid) containing all
four nucleobases to the fully complementary as well as various singly mismatched RNA and …

Melting temperatures, T m, were systematically studied for a set of 92 DNA duplex oligomers
in a variety of sodium ion concentrations ranging from 69 mM to 1.02 M. The relationship …

Abstract Peptide Nucleic Acid (PNA) is a powerful new biomolecular tool with a wide range
of important applications. PNA mimics the behaviour of DNA and binds complementary …

The astonishing discovery that peptide nucleic acids (PNAs, B= nucleobase), in spite of their
drastic structural difference to natural DNA, are better nucleic acid mimetics than many other …

Peptide nucleic acid (PNA) is arguably one of the most successful DNA mimics, despite a
most dramatic departure from the native structure of DNA. The present review summarizes …