Monoamine oxidase enzyme is necessary for the management of brain functions. It
oxidatively metabolizes monoamines and produces ammonia, aldehyde and hydrogen …

Alzheimer's disease (AD) is multifactorial, progressive and the most predominant cause of
cognitive impairment and dementia worldwide. The current “one-drug, one-target” approach …

In the current work, Schiff base derivatives of antipyrine were synthesized. The chemical
characterization of the compounds was confirmed using IR, 1 H NMR, 13 C NMR and mass …

The pharmaceutical industry is increasingly joining chemoinformatics in the search for the
development of new drugs to be used in the treatment of diseases. These computational …

Human farnesyl pyrophosphate synthase (hFPPS) is a well-settled therapeutic target and it
is an enzyme of the mevalonate pathway which catalyzes the biosynthesis of the C-15 …

Phenyl-3-(thiophen-2-yl)-1 H-pyrazole-5-carboxamide derivatives were designed and
evaluated for their in vitro enzyme inhibitory activities against acetylcholinesterase (AChE) …

Candida albicans infections and their resistance to clinically approved azole drugs are
major concerns for human. The azole antifungal drugs inhibit the ergosterol synthesis by …

Since the last century, when scientists proposed the lock-and-key model, the discovery of
drugs has focused on the development of drugs acting on single target. However, single …

Background: Pyrazole is one of the excellent structural motifs in medicinal chemistry.
Various physiological and therapeutic possibilities have been exploited by incorporating …

Alzheimer's Disease (AD) is a single major cause of dementia in middle to old age
individuals involving several different etiopathological mechanisms that are yet to be …