Cell free circulating tumor DNA in cerebrospinal fluid detects and monitors central nervous system involvement of B-cell lymphomas
The levels of cell free circulating tumor DNA (ctDNA) in plasma correlate with treatment
response and outcome in systemic lymphomas. Notably, in brain tumors, the levels of ctDNA …
response and outcome in systemic lymphomas. Notably, in brain tumors, the levels of ctDNA …
Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment
C Rubio-Perez, E Planas-Rigol, JL Trincado… - Nature …, 2021 - nature.com
Brain metastases are the most common tumor of the brain with a dismal prognosis. A fraction
of patients with brain metastasis benefit from treatment with immune checkpoint inhibitors …
of patients with brain metastasis benefit from treatment with immune checkpoint inhibitors …
Colonization and genetic diversification processes of Leishmania infantum in the Americas
Leishmania infantum causes visceral leishmaniasis, a deadly vector-borne disease
introduced to the Americas during the colonial era. This non-native trypanosomatid parasite …
introduced to the Americas during the colonial era. This non-native trypanosomatid parasite …
An FPGA accelerator of the wavefront algorithm for genomics pairwise alignment
In the last years, advances in next-generation sequencing technologies have enabled the
proliferation of genomic applications that guide personalized medicine. These applications …
proliferation of genomic applications that guide personalized medicine. These applications …
WFA-FPGA: An efficient accelerator of the wavefront algorithm for short and long read genomics alignment
In the last years, advances in genome sequencing technologies have enabled the
proliferation of genomic applications that guide personalized medicine. These applications …
proliferation of genomic applications that guide personalized medicine. These applications …
Polymer modelling unveils the roles of heterochromatin and nucleolar organizing regions in shaping 3D genome organization in Arabidopsis thaliana
M Di Stefano, HW Nützmann… - Nucleic Acids …, 2021 - academic.oup.com
The 3D genome is characterized by a complex organization made of genomic and
epigenomic layers with profound implications on gene regulation and cell function …
epigenomic layers with profound implications on gene regulation and cell function …
Benchmarking of Whole Exome Sequencing and Ad Hoc Designed Panels for Genetic Testing of Hereditary Cancer
L Feliubadaló, R Tonda, M Gausachs, JR Trotta… - Scientific reports, 2017 - nature.com
Next generation sequencing panels have been developed for hereditary cancer, although
there is some debate about their cost-effectiveness compared to exome sequencing. The …
there is some debate about their cost-effectiveness compared to exome sequencing. The …
New evaluation methods of read mapping by 17 aligners on simulated and empirical NGS data: an updated comparison of DNA-and RNA-Seq data from Illumina and …
L Donato, C Scimone, C Rinaldi, R D'Angelo… - Neural Computing and …, 2021 - Springer
Abstract During the last (15) years, improved omics sequencing technologies have
expanded the scale and resolution of various biological applications, generating high …
expanded the scale and resolution of various biological applications, generating high …
WFAsic: A High-Performance ASIC Accelerator for DNA Sequence Alignment on a RISC-V SoC
The ever-increasing yields in genome sequence data production pose a computational
challenge to current genome sequence analysis tools, jeopardizing the future of …
challenge to current genome sequence analysis tools, jeopardizing the future of …
Novel computational techniques for mapping and classification of Next-Generation Sequencing data
K Brinda - 2016 - hal.science
Since their emergence around 2006, Next-Generation Sequencing technologies have been
revolutionizing biological and medical research. Obtaining instantly an extensive amount of …
revolutionizing biological and medical research. Obtaining instantly an extensive amount of …