Parkinson's disease (PD) is the second leading neurodegenerative disease globally,
impacting the quality of life of millions of people. It is estimated that the treatment cost of PD …

Motor complications related to the chronic administration of levodopa and failure to prevent
the neurodegenerative disease process counterbalance the pivotal discovery of levodopa …

The trajectory of the use of dopamine replacement therapy (DRT) in Parkinson's disease
(PD) is variable and doses may need to be increased, but also tapered. The plan for dose …

Introduction Levodopa is the most effective medication for the treatment of motor symptoms
of Parkinson's disease (PD). Several factors may affect the efficacy and tolerability of …

Radiotherapy (RT) is commonly used to try to eliminate any remaining tumor cells following
surgical resection of glioma. However, tumor recurrence is prevalent, highlighting the unmet …

The use of clinical psychoactive drugs often poses unpredictable threats to fetal
development. Catechol-O-methyltransferase (COMT) is a key enzyme that regulates …

Background Opicapone (OPC) is a third-generation, selective peripheral COMT inhibitor that
improves peripheral L-DOPA bioavailability and reduces OFF time and end-of-dose motor …

Catechol-O-methyltransferase (COMT) plays a central role in the metabolic inactivation of
endogenous neurotransmitters and xenobiotic drugs and hormones having catecholic …

Neurodegenerative diseases (NDs) are one of the prominent health challenges facing
contemporary society, and many efforts have been made to overcome and (or) control it. In …

Aim: This subanalysis of the OPTIPARK study aimed to confirm the effectiveness and safety
of opicapone in patients with Parkinson's disease and motor fluctuations in clinical practice …