Actively targeted gold-polydopamine (PDA@ Au) nanocomplex for sequential drug release and combined synergistic chemo-photothermal therapeutic effects

S Singh, K Pal - International Journal of Pharmaceutics, 2023 - Elsevier
Multifunctional nanoparticles for treatment in cancer are getting more and more attention
recently. In this study, we employed a novel polydopamine (PDA) framework-based gold …

Abiraterone Acetate Complexes with Biometals: Synthesis, Characterization in Solid and Solution, and the Nature of Chemical Bonding

P Buikin, A Vologzhanina, R Novikov, P Dorovatovskii… - Pharmaceutics, 2023 - mdpi.com
Abiraterone acetate (AbirAc) is the most used steroidal therapeutic agent for treatment of
prostate cancer. The mainly hydrophobic molecular surface of AbirAc results in its poor …

Pharmaceutical cocrystals: Unlocking the potential of challenging drug candidates

J Pantwalawalkar, N Kale, S Nangare, S Patil… - Journal of Drug Delivery …, 2024 - Elsevier
Pharmaceutical development is often limited by drugs with unfavorable physicochemical
properties, such as poor solubility, limited permeability, and low bioavailability, which …

A Comprehensive Review on Theoretical Screening Methods for Pharmaceutical Cocrystals

J Roshni, T Karthick - Journal of Molecular Structure, 2025 - Elsevier
In crystal engineering, cocrystallization has become one of the preferred methods for
improving the physicochemical properties of active pharmaceutical ingredients (APIs). The …

Rational Design of the Carbamazepine Ternary Cocrystals

DE Boycov, KV Drozd, AN Manin… - Crystal Growth & …, 2024 - ACS Publications
The first ternary cocrystals of carbamazepine (CBZ) were successfully identified through a
large-scale screening. A design strategy involved the use of an aliphatic dicarboxylic acid to …

Unraveling a Unique Metastable Phase of a Proxyphylline Cocrystal Exclusively Produced by Compressed Carbon Dioxide

F Ercicek, M Marchivie, L Nimod, H Cercel… - Crystal Growth & …, 2024 - ACS Publications
In this work, racemic proxyphylline ((±)-PXL, a chiral drug) was cocrystallized for the first time
with 4-hydroxybenzoic acid (4-HBA) from three solvents (acetone, ethyl acetate, and …

Two novel drug-nutraceutical cocrystal hydrates of carbamazepine: The influence of isomerism in trihydroxybenzoic acids on the in vitro/in vivo properties

DE Boycov, KV Drozd, AN Manin, AV Churakov… - Journal of Molecular …, 2024 - Elsevier
Two novel drug-nutraceutical cocrystal hydrates based on the antiepileptic carbamazepine
(CBZ) with isomeric trihydroxybenzoic acids, including 3, 4, 5-trihydroxybenzoic acid …

Structural and vibrational spectral analysis of polymorphs of anhydrous Acyclovir Using terahertz and Raman spectroscopy

Q Zhao, J Zhang, Y Jing, J Xue, J Liu, J Qin, Z Hong… - Chemical Physics, 2025 - Elsevier
Acyclovir (ACV), a prototypical antiviral drug, exhibits distinct physicochemical properties
due to its polymorphism. In this study, two stable anhydrous forms of ACV were prepared at …

Advances in solvent based cocrystallization: Bridging the gap between theory and practice

S Sarangi, PN Remya, N Damodharan - Journal of Drug Delivery Science …, 2024 - Elsevier
A common tactic in materials science and pharmaceuticals is cocrystallization, which
synthesises multi-component crystalline materials with unique physicochemical …

Two crystalline polymorphs of voriconazole− 2, 4− dihydroxybenzoic acid cocrystals

N Gong, Y Zou, S Yang, X Meng, H Yu, G He… - Journal of Molecular …, 2025 - Elsevier
In this work, two novel voriconazole and 2, 4− dihydroxybenzoic acid cocrystal polymorphs
(Form A and B) were harvested using liquid-assisted grinding method with a mortar and …