BK polyomavirus: clinical aspects, immune regulation, and emerging therapies

GR Ambalathingal, RS Francis, MJ Smyth… - Clinical microbiology …, 2017 - Am Soc Microbiol
SUMMARY BK polyomavirus (BKV) causes frequent infections during childhood and
establishes persistent infections within renal tubular cells and the uroepithelium, with …

BK virus nephropathy and kidney transplantation

DL Bohl, DC Brennan - Clinical Journal of the American Society of …, 2007 - journals.lww.com
Nephropathy from BK virus (BKV) infection is an evolving challenge in kidney transplant
recipients. It is the consequence of modern potent immunosuppression aimed at reducing …

BK polyomavirus in solid organ transplantation—Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice

HH Hirsch, PS Randhawa… - Clinical …, 2019 - Wiley Online Library
The present AST‐IDCOP guidelines update information on BK polyomavirus (BKP yV)
infection, replication, and disease, which impact kidney transplantation (KT), but rarely non …

The decade of polyomavirus BK-associated nephropathy: state of affairs

E Ramos, CB Drachenberg, R Wali, HH Hirsch - Transplantation, 2009 - journals.lww.com
In the last 10 years, better immunosuppression drugs have decreased the rates of acute
rejection in kidney transplantation but have also led to the emergence of polyomavirus …

Progressive multifocal leukoencephalopathy and use of mycophenolate mofetil after kidney transplantation

RT Neff, FP Hurst, EM Falta, EM Bohen… - …, 2008 - journals.lww.com
Mycophenolate mofetil (MMF) use may be associated with progressive multifocal
leukoencephalopathy (PML). We conducted a retrospective cohort study of 32,757 renal …

BK polyomavirus-specific antibody and T-cell responses in kidney transplantation: update

A Kaur, M Wilhelm, S Wilk… - Current opinion in …, 2019 - journals.lww.com
BK polyomavirus-specific antibody and T-cell responses in ki... : Current Opinion in Infectious
Diseases BK polyomavirus-specific antibody and T-cell responses in kidney transplantation …

Functional Characterization of BK Virus-Specific CD4+ T Cells with Cytotoxic Potential in Seropositive Adults

W Zhou, M Sharma, J Martinez, T Srivastava… - Viral …, 2007 - liebertpub.com
BK polyomavirus (BKV) reactivation is associated with a failure of T cell immunity in kidney
transplant patients, and may lead to BKV-associated nephropathy (BKVN) and loss of the …

BK virus-specific T cells for use in cellular therapy show specificity to multiple antigens and polyfunctional cytokine responses

E Blyth, L Clancy, R Simms, S Gaundar… - …, 2011 - journals.lww.com
Background. BK virus (BKV) infection causes hemorrhagic cystitis posthemopoietic stem-cell
transplant and graft loss in renal transplant recipients. Reactivation occurs in up to 60% of …

The effect of BK polyomavirus large T antigen on CD4 and CD8 T cells in kidney transplant recipients

MR Foroudi, R Yaghobi, A Afshari, J Roozbeh… - Transplant …, 2022 - Elsevier
Human BK polyomavirus (BKPyV) can affect the machinery of the host cell to induce optimal
viral replication or transform them into tumor cells. Reactivation of BKPyV happens due to …

VP‐1 quasispecies in human infection with polyomavirus BK

C Luo, HH Hirsch, J Kant… - Journal of medical …, 2012 - Wiley Online Library
Polyomavirus BK is a recognized cause of nephropathy and hemorrhagic cystitis in kidney
or allogeneic hematopoietic stem cell transplant recipients. This study explored a role of …