NK cells and cancer: you can teach innate cells new tricks
Natural killer (NK) cells are the prototype innate lymphoid cells endowed with potent cytolytic
function that provide host defence against microbial infection and tumours. Here, we review …
function that provide host defence against microbial infection and tumours. Here, we review …
Targeting natural killer cells in solid tumors
G Habif, A Crinier, P André, E Vivier… - Cellular & molecular …, 2019 - nature.com
Natural killer (NK) cells are innate lymphoid cells endowed with cytolytic activity and a
capacity to secrete cytokines and chemokines. Several lines of evidence suggest that NK …
capacity to secrete cytokines and chemokines. Several lines of evidence suggest that NK …
Biology of natural killer cells
G Trinchieri - Advances in immunology, 1989 - Elsevier
Publisher Summary Studies of cytotoxicity by human lymphocytes revealed not only that
both allogeneic and syngeneic tumor cells were lysed in a non-MHC-restricted fashion, but …
both allogeneic and syngeneic tumor cells were lysed in a non-MHC-restricted fashion, but …
Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population
K Imai, S Matsuyama, S Miyake, K Suga, K Nakachi - The lancet, 2000 - thelancet.com
Background One of the most critical questions in immunosurveillance is whether differences
between individuals with regards to natural immunological host defence can predict future …
between individuals with regards to natural immunological host defence can predict future …
[PDF][PDF] Biology and clinical relevance of human natural killer cells
MJ Robertson, J Ritz - 1990 - researchgate.net
ATURAL KILLER (NK) cells comprise 10% to 15% N of human peripheral blood
lymphocytes (PBL) and most have the morphology of large granular lymphocytes (LGL).'s2 …
lymphocytes (PBL) and most have the morphology of large granular lymphocytes (LGL).'s2 …
Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells
G Ferlazzo, ML Tsang, L Moretta, G Melioli… - The Journal of …, 2002 - rupress.org
During the innate response to many inflammatory and infectious stimuli, dendritic cells (DCs)
undergo a differentiation process termed maturation. Mature DCs activate antigen-specific …
undergo a differentiation process termed maturation. Mature DCs activate antigen-specific …
Human immunity against EBV—lessons from the clinic
The mammalian immune system has evolved over many millennia to be best equipped to
protect the host from pathogen infection. In many cases, host and pathogen have coevolved …
protect the host from pathogen infection. In many cases, host and pathogen have coevolved …
Therapeutic potential and challenges of natural killer cells in treatment of solid tumors
A Gras Navarro, AT Björklund, M Chekenya - Frontiers in immunology, 2015 - frontiersin.org
Natural killer (NK) cells are innate lymphoid cells that hold tremendous potential for effective
immunotherapy for a broad range of cancers. Due to the mode of NK cell killing, requiring …
immunotherapy for a broad range of cancers. Due to the mode of NK cell killing, requiring …
[HTML][HTML] Human natural killer cell deficiencies and susceptibility to infection
JS Orange - Microbes and Infection, 2002 - Elsevier
There are a surprisingly large number of human natural killer (NK) cell deficiency states that
provide insight into the role of NK cells in defense against human infectious disease. Many …
provide insight into the role of NK cells in defense against human infectious disease. Many …
The production of monoclonal antibodies from human lymphocytes
D Kozbor, JC Roder - Immunology Today, 1983 - cell.com
Two conceptually unique approaches are currently available for the production of human
monoclonal antibodiesthe'hybridoma'technique, based on the fusion of antibody-producing …
monoclonal antibodiesthe'hybridoma'technique, based on the fusion of antibody-producing …