Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …

Parkinson's disease (PD) is a complex, multi-system neurodegenerative disorder. The
second most common neurodegenerative disorder after Alzheimer's disease, it affects …

Neural recordings using invasive devices in humans can elucidate the circuits underlying
brain disorders, but have so far been limited to short recordings from externalized brain …

The miniaturization, sophistication, proliferation, and accessibility of technologies are
enabling the capture of more and previously inaccessible phenomena in Parkinson's …

Beta oscillations (∼ 13 to 30 Hz) have been observed during many perceptual, cognitive,
and motor processes in a plethora of brain recording studies. Although the function of beta …

Parkinson disease (PD) treatment options have conventionally focused on dopamine
replacement and provision of symptomatic relief. Current treatments cause undesirable …

Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …

Adaptive deep brain stimulation uses feedback about the state of neural circuits to control
stimulation rather than delivering fixed stimulation all the time, as currently performed. In …

Despite long-term and widespread use of deep brain stimulation (DBS) in a variety of
neurological conditions, the underlying mechanisms of action have been elusive. Growing …

Techniques for neuromodulation serve as effective routes to care of patients with many types
of challenging conditions. Continued progress in this field of medicine will require (1) …