Personalized medicine tailors therapies, disease prevention, and health maintenance to the
individual, with pharmacogenomics serving as a key tool to improve outcomes and prevent …

Background: Next-generation sequencing (NGS) methods have become more commonly
performed in clinical and research laboratories. Methods: This review summarizes the …

Clopidogrel is widely used worldwide as an antiplatelet therapy in patients with acute
coronary disease. Genetic factors influence interindividual variability in response. Some …

Background: Pharmacogenomic knowledge as a biomarker for cancer care has transformed
clinical practice, however, as current guidelines are primarily derived from Eurocentric …

Adverse drug reactions (ADRs) pose substantial public health issues, necessitating
population-specific characterization due to variations in pharmacogenes. This study …

Background: Genetic interindividual variability is associated with adverse drug reactions
(ADRs) and affects the response to common drugs used in anesthesia. Despite their …

Background Syntaxin 1A is a member of a membrane-integrated nervous system-specific
protein superfamily involved in the neuromediator release from synaptic vesicles and one of …

Objective A low incidence and mortality rate of cancer has been observed in high-altitude
regions, suggesting a potential positive effect of low press and hypoxia (LPH) environment …

El gen citocromo P450 2D6 (CYP2D6) es altamente polimórfico que codifican enzimas que
metabolizan más del 25% de los fármacos de uso clínico; siendo CYP2D6* 3 y CYP2D6* 4 …

Gran parte de la toxicidad en pacientes oncológicos tratados con fluoropirimidinas se debe
a la pérdida de la actividad enzimática de la dihidropiridina deshidrogenasa, causada por …