[HTML][HTML] Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms

H Slika, H Mansour, N Wehbe, SA Nasser… - Biomedicine & …, 2022 - Elsevier
Cancer is a leading cause of morbidity and mortality around the globe. Reactive oxygen
species (ROS) play contradicting roles in cancer incidence and progression. Antioxidants …

Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease

E Zaplatic, M Bule, SZA Shah, MS Uddin, K Niaz - Life sciences, 2019 - Elsevier
Quercetin belongs to the flavonoids family, which is present in most of the plants including
fruits, vegetables, green tea and even in red wine having antioxidant activities. It is available …

Regulation of Nrf2/ARE pathway by dietary flavonoids: a friend or foe for cancer management?

T L. Suraweera, HPV Rupasinghe, G Dellaire, Z Xu - Antioxidants, 2020 - mdpi.com
The nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE)
pathway is an important cell signaling mechanism in maintaining redox homeostasis in …

Modulation of metabolic detoxification pathways using foods and food‐derived components: a scientific review with clinical application

RE Hodges, DM Minich - Journal of nutrition and metabolism, 2015 - Wiley Online Library
Research into human biotransformation and elimination systems continues to evolve.
Various clinical and in vivo studies have been undertaken to evaluate the effects of foods …

Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence

L Chen, H Teng, Z Jia, M Battino, A Miron… - Critical reviews in …, 2018 - Taylor & Francis
Dietary flavonoids, which occur in many plant foods, are considered as the most active
constituents among the plant-derived ones in vitro and in vivo. To date, many studies have …

Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation

Y Bai, W Cui, Y Xin, X Miao, MT Barati, C Zhang… - Journal of molecular and …, 2013 - Elsevier
This study was to investigate whether sulforaphane (SFN) can prevent diabetic
cardiomyopathy. Type 1 diabetes was induced in FVB mice by multiple intraperitoneal …

Metallothionein is downstream of Nrf2 and partially mediates sulforaphane prevention of diabetic cardiomyopathy

J Gu, Y Cheng, H Wu, L Kong, S Wang, Z Xu… - Diabetes, 2017 - Am Diabetes Assoc
We have reported that sulforaphane (SFN) prevented diabetic cardiomyopathy in both type 1
and type 2 diabetes (T2DM) animal models via the upregulation of nuclear transcription …

Neuroprotective potentials of flavonoids: Experimental studies and mechanisms of action

P Bellavite - Antioxidants, 2023 - mdpi.com
Neurological and neurodegenerative diseases, particularly those related to aging, are on
the rise, but drug therapies are rarely curative. Functional disorders and the organic …

The involvement of p62–Keap1–Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity

LL Ji, YC Sheng, ZY Zheng, L Shi, ZT Wang - Free Radical Biology and …, 2015 - Elsevier
Quercetin, one of the most abundant dietary flavonoids, is reported to have protective
function against various hepatotoxicant-induced hepatotoxicity. The present study aims to …

[HTML][HTML] New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation

L Zhang, LY Xu, F Tang, D Liu, XL Zhao… - Journal of …, 2024 - Elsevier
Abstract Non-communicable diseases (NCDs), including cardiovascular diseases, cancer,
metabolic diseases, and skeletal diseases, pose significant challenges to public health …