Dynamic covalent polymers for biomedical applications

Y Zhang, Y Qi, S Ulrich, M Barboiu… - Materials chemistry …, 2020 - pubs.rsc.org
The rapid development of supramolecular polymer chemistry and constitutional dynamic
chemistry over the last decades has made tremendous impact on the emergence of dynamic …

Nanomedicine-based delivery strategies for nucleic acid gene inhibitors in inflammatory diseases

E Fattal, F Fay - Advanced drug delivery reviews, 2021 - Elsevier
Thanks to their abilities to modulate the expression of virtually any genes, RNA therapeutics
have attracted considerable research efforts. Among the strategies focusing on nucleic acid …

Treatment of acute lung inflammation by pulmonary delivery of anti-TNF-α siRNA with PAMAM dendrimers in a murine model

A Bohr, N Tsapis, C Foged, I Andreana, M Yang… - European Journal of …, 2020 - Elsevier
To improve the efficacy of nucleic acid-based therapeutics, eg, small interfering RNA
(siRNA), transfection agents are needed for efficient delivery into cells. Several classes of …

On the Power and Challenges of Atomistic Molecular Dynamics to Investigate RNA Molecules

S Muscat, G Martino, J Manigrasso… - Journal of Chemical …, 2024 - ACS Publications
RNA molecules play a vital role in biological processes within the cell, with significant
implications for science and medicine. Notably, the biological functions exerted by specific …

[HTML][HTML] Enhancing siRNA cancer therapy: Multifaceted strategies with lipid and polymer-based carrier systems

NK Dastgerdi, NK Dastgerdi, H Bayraktutan… - International Journal of …, 2024 - Elsevier
Cancers are increasing in prevalence and many challenges remain for their treatment, such
as chemoresistance and toxicity. In this context, siRNA-based therapeutics have many …

Nanoparticulate drug delivery to the retina

Q Li, J Weng, SN Wong, WY Thomas Lee… - Molecular …, 2020 - ACS Publications
Retinal diseases, such as age-related macular degeneration and diabetic retinopathy, are
the leading causes of blindness worldwide. The mainstay of treatment for these blinding …

Janus-type dendrimers: Synthesis, properties, and applications

F Najafi, M Salami-Kalajahi… - Journal of Molecular …, 2022 - Elsevier
Dendrimers are among the most popular multifaceted systems. Conventional dendrimers
cannot be used in many specific applications such as simultaneous loading of different …

In vivo therapeutic applications of phosphorus dendrimers: State of the art

S Mignani, X Shi, V Ceña, D Shcharbin… - Drug Discovery …, 2021 - Elsevier
Among the different types of dendrimers, those that incorporate phosphorus in various
positions in their structures present fascinating properties and have wide applications in …

In vitro validation of the therapeutic potential of dendrimer-based nanoformulations against tumor stem cells

N Knauer, V Arkhipova, G Li, M Hewera… - International Journal of …, 2022 - mdpi.com
Tumor cells with stem cell properties are considered to play major roles in promoting the
development and malignant behavior of aggressive cancers. Therapeutic strategies that …

Computer Aided Development of Nucleic Acid Applications in Nanotechnologies

M Paloncýová, M Pykal, P Kührová, P Banáš, J Šponer… - Small, 2022 - Wiley Online Library
Utilization of nucleic acids (NAs) in nanotechnologies and nanotechnology‐related
applications is a growing field with broad application potential, ranging from biosensing up …