Advances in hepatitis B therapeutics

V Soriano, P Barreiro, E Cachay… - Therapeutic …, 2020 - journals.sagepub.com
Despite the availability of both effective preventive vaccines and oral antivirals, over 250
million people are chronically infected with the hepatitis B virus (HBV). Globally, chronic …

Extending treatment eligibility for chronic hepatitis B virus infection

AL McNaughton, M Lemoine, C van Rensburg… - Nature Reviews …, 2021 - nature.com
Progress towards hepatitis B virus (HBV) elimination targets remains slow, despite efforts to
support enhanced prevention, diagnosis and treatment. On the basis of insights from …

Guidelines for the prevention and treatment of chronic hepatitis B (version 2022)

H You, FS Wang, T Li, X Xu, Y Sun, Y Nan… - Infectious Diseases & …, 2023 - mednexus.org
To facilitate the achieving of the goal of" eliminating viral hepatitis as a major public health
threat by 2030" set by the World Health Organization, the Chinese Society of Hepatology …

[HTML][HTML] Hepatocellular carcinoma risk in patients with chronic hepatitis B receiving tenofovir-vs. entecavir-based regimens: Individual patient data meta-analysis

WM Choi, TCF Yip, GLH Wong, WR Kim, LJ Yee… - Journal of …, 2023 - Elsevier
Background & Aims The comparative risk of hepatocellular carcinoma (HCC) in patients with
chronic hepatitis B (CHB) receiving tenofovir disoproxil fumarate (TDF) vs. entecavir (ETV) …

Distribution and clinical characteristics of patients with chronic hepatitis B virus infection in the grey zone

K Yao, J Liu, J Wang, X Yan, J Xia, Y Yang… - Journal of Viral …, 2021 - Wiley Online Library
A substantial proportion of patients with chronic hepatitis B (CHB) who do not fit into any of
the usual immune states are considered to be in the 'grey zone (GZ)'. We aimed to …

[HTML][HTML] Sexual dimorphism in chronic hepatitis B virus (HBV) infection: evidence to inform elimination efforts

R Brown, P Goulder, PC Matthews - Wellcome Open Research, 2022 - ncbi.nlm.nih.gov
Sexual dimorphism in infectious diseases refers to the different infection susceptibilities and
outcomes between males and females, and has been described for many pathogens …

Chronic hepatitis B: the demise of the 'inactive carrier'phase

A Koffas, M Kumar, US Gill, A Jindal… - Hepatology …, 2021 - Springer
Chronic hepatitis B (CHB) remains a global healthcare burden. Although the recent
developments in the field have led to a reduction in incidence, the morbidity and mortality …

[HTML][HTML] What will it take to cure hepatitis B?

WJ Jeng, ASF Lok - Hepatology Communications, 2023 - journals.lww.com
The current treatment of chronic HBV infection, pegylated interferon-α (pegIFNα) and
nucleos (t) ide analog (NA), can suppress HBV replication, reverse liver inflammation and …

Predictive models for functional cure in patients with CHB receiving PEG-IFN therapy based on HBsAg quantification through meta-analysis

PX Zhang, QQ Tang, J Zhu, WY Deng… - Hepatology international, 2024 - Springer
Background and aims The efficacy of achieving HBsAg clearance through pegylated
interferon (PEG-IFNα) therapy in patients with chronic hepatitis B (CHB) remains uncertain …

[HTML][HTML] Hepatitis B: Who should be treated?-managing patients with chronic hepatitis B during the immune-tolerant and immunoactive phases

M Kawanaka, K Nishino, H Kawamoto… - World Journal of …, 2021 - ncbi.nlm.nih.gov
New hepatitis B virus (HBV) infections are decreasing owing to improved antiviral therapy
and increased HBV vaccination worldwide; however, the number of HBV infections remains …