The transition between epithelial and mesenchymal phenotype is emerging as a key
determinant of tumor cell invasion and metastasis. It is a plastic process in which epithelial …

Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …

Cancer cells display a high rate of glycolysis in the presence of oxygen to promote
proliferation. Gluconeogenesis, the reverse pathway of glycolysis, can antagonize aerobic …

Cancer cells must adapt their metabolism to meet the energetic and biosynthetic demands
that accompany rapid growth of the primary tumor and colonization of distinct metastatic …

Rapidly growing malignant tumors frequently encounter hypoxia and nutrient (eg, glucose)
deprivation, which occurs because of insufficient blood supply. This results in necrotic cell …

Breast cancer is a leading cause of death among women worldwide. Dysbiosis, an aberrant
composition of the microbiome, characterizes breast cancer. In this review we discuss the …

Background Nucleotide metabolism is a critical pathway that generates purine and
pyrimidine molecules for DNA replication, RNA synthesis, and cellular bioenergetics …

Cancer metabolic reprogramming enhances its malignant behaviors and drug resistance,
which is regulated by POU domain transcription factors. This study explored the effect of …

Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ)
are the downstream effectors of the Hippo signaling pathway that play a crucial role in …

In the last few decades, the role of cancer stem cells in initiating tumors, metastasis,
invasion, and resistance to therapies has been recognized as a potential target for tumor …