Diabetes mellitus predisposes affected individuals to a significant spectrum of
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …

Cardiovascular disease remains the principal cause of death and disability among patients
with diabetes mellitus. Diabetes mellitus exacerbates mechanisms underlying …

Even in the absence of coronary artery disease and hypertension, diabetes mellitus (DM)
may increase the risk for heart failure development. This risk evolves from functional and …

Diabetes mellitus-related cardiomyopathy (DMCMP) was originally described as a dilated
phenotype with eccentric left ventricular (LV) remodelling and systolic LV dysfunction …

Oxidative stress occurs whenever the release of reactive oxygen species (ROS) exceeds
endogenous antioxidant capacity. In this paper, we review the specific role of several …

Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic
population. Both experimental and clinical evidence suggest that diabetic subjects are …

Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …

Diabetic cardiomyopathy (DCM) is a cardiac dysfunction which affects approximately 12% of
diabetic patients, leading to overt heart failure and death. However, there is not an efficient …

Background—Prominent features of myocardial remodeling in heart failure with preserved
ejection fraction (HFPEF) are high cardiomyocyte resting tension (Fpassive) and …

Diabetes is associated with increased incidence of heart failure even after controlling for
coronary artery disease and hypertension. Thus, as diabetic cardiomyopathy has become …