Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

Protein-protein interactions are fundamental to the formation of intricate interaction networks
and the assembly of multisubunit protein complexes that represent the functional …

Efficient movement of proteins across membranes is required for cell health. The
translocation process is particularly challenging when the channel in the membrane through …

The biogenesis of mitochondria depends on the import of hundreds of preproteins. N-
terminal matrix-targeting signals (MTSs) direct preproteins to the surface receptors Tom20 …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) expresses high
amounts of the protein Orf9b to target the mitochondrial outer membrane protein Tom70 …

Tom70 is a versatile adaptor protein of 70 kDa anchored in the outer membrane of
mitochondria in metazoa, fungi and amoeba. The tertiary structure was resolved for the …

Mitochondria are essential organelles of eukaryotic cells. They consist of hundreds of
different proteins that exhibit crucial activities in respiration, catabolic metabolism and the …

Connexins are known for their ability to mediate cell-cell communication via gap junctions
and also form hemichannels that pass ions and molecules over the plasma membrane when …

Mitochondrial biogenesis has two major steps: the transcriptional activation of nuclear
genome-encoded mitochondrial proteins and the import of nascent mitochondrial proteins …

Mitochondrial protein import is one of the key processes during mitochondrial biogenesis
that involves a series of events necessary for recognition and delivery of nucleus …