Immune cell development and activation demand the precise and coordinated control of
transcriptional programmes. Three-dimensional (3D) organization of the genome has …

Genes encoding subunits of SWI/SNF chromatin remodeling complexes are collectively
mutated in 20% of all human cancers. ARID1A is the SWI/SNF subunit gene that is most …

Myeloid neoplasms are clonal hematopoietic stem cell disorders driven by the sequential
acquisition of recurrent genetic lesions. Truncating mutations in the chromatin remodeler …

Although the study of leukemogenesis has traditionally focused on protein-coding genes,
the role of enhancer dysregulation is becoming increasingly recognized. The advent of high …

Cancer cell heterogeneity is a major driver of therapy resistance. To characterize resistant
cells and their vulnerabilities, we studied the PLZF-RARA variant of acute promyelocytic …

Sequencing-based mapping of ensemble pairwise interactions among regulatory elements
support the existence of topological assemblies known as promoter-enhancer hubs or …

The promising activity of BET protein inhibitors (BETi's) is compromised by adaptive or
innate resistance in acute myeloid leukemia (AML). Here, modeling of BETi …

Quebec platelet disorder (QPD) is an autosomal dominant bleeding disorder with a unique,
platelet-dependent, gain-of-function defect in fibrinolysis, without systemic fibrinolysis. The …

B cell lineage acute lymphoblastic leukemia (B-ALL) is composed of diverse molecular
subtypes, and while transcriptional and DNA methylation profiling has been extensively …

Background Enhancer reprogramming plays a significant role in the heterogeneity of cancer.
However, we have limited knowledge about the impact of chromatin remodeling in B-Cell …