Sculpting neural circuits by axon and dendrite pruning

MM Riccomagno, AL Kolodkin - Annual review of cell and …, 2015 - annualreviews.org
The assembly of functional neural circuits requires the combined action of progressive and
regressive events. Regressive events encompass a variety of inhibitory developmental …

A mechanistic understanding of axon degeneration in chemotherapy-induced peripheral neuropathy

Y Fukuda, Y Li, RA Segal - Frontiers in neuroscience, 2017 - frontiersin.org
Chemotherapeutic agents cause many short and long term toxic side effects to peripheral
nervous system (PNS) that drastically alter quality of life. Chemotherapy-induced peripheral …

Syncytial nerve net in a ctenophore adds insights on the evolution of nervous systems

P Burkhardt, J Colgren, A Medhus, L Digel, B Naumann… - Science, 2023 - science.org
A fundamental breakthrough in neurobiology has been the formulation of the neuron
doctrine by Santiago Ramón y Cajal, which stated that the nervous system is composed of …

Alternative neural systems: what is a neuron?(ctenophores, sponges and placozoans)

LL Moroz, DY Romanova - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
How to make a neuron, a synapse, and a neural circuit? Is there only one 'design'for a
neural architecture with a universally shared genomic blueprint across species? The brief …

Mechanisms of developmental neurite pruning

O Schuldiner, A Yaron - Cellular and Molecular Life Sciences, 2015 - Springer
The precise wiring of the nervous system is a combined outcome of progressive and
regressive events during development. Axon guidance and synapse formation intertwined …

Steroid hormone induction of temporal gene expression in Drosophila brain neuroblasts generates neuronal and glial diversity

MH Syed, B Mark, CQ Doe - Elife, 2017 - elifesciences.org
An important question in neuroscience is how stem cells generate neuronal diversity. During
Drosophila embryonic development, neural stem cells (neuroblasts) sequentially express …

High fat diet induces microbiota-dependent silencing of enteroendocrine cells

L Ye, O Mueller, J Bagwell, M Bagnat, RA Liddle… - Elife, 2019 - elifesciences.org
Enteroendocrine cells (EECs) are specialized sensory cells in the intestinal epithelium that
sense and transduce nutrient information. Consumption of dietary fat contributes to …

Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila

H Meltzer, E Marom, I Alyagor, O Mayseless… - Nature …, 2019 - nature.com
Gene editing by CRISPR/Cas9 is commonly used to generate germline mutations or perform
in vitro screens, but applicability for in vivo screening has so far been limited. Recently, it …

Drosophila postembryonic nervous system development: a model for the endocrine control of development

JW Truman, LM Riddiford - Genetics, 2023 - academic.oup.com
During postembryonic life, hormones, including ecdysteroids, juvenile hormones, insulin-like
peptides, and activin/TGFβ ligands act to transform the larval nervous system into an adult …

Anastasis: recovery from the brink of cell death

HM Tang, HL Tang - Royal Society open science, 2018 - royalsocietypublishing.org
Anastasis is a natural cell recovery phenomenon that rescues cells from the brink of death.
Programmed cell death such as apoptosis has been traditionally assumed to be an …