β-Barrel membrane protein assembly by the Bam complex

CL Hagan, TJ Silhavy, D Kahne - Annual review of biochemistry, 2011 - annualreviews.org
β-barrel membrane proteins perform important functions in the outer membranes (OMs) of
Gram-negative bacteria and of the mitochondria and chloroplasts of eukaryotes. The protein …

Membrane protein architects: the role of the BAM complex in outer membrane protein assembly

TJ Knowles, A Scott-Tucker, M Overduin… - Nature Reviews …, 2009 - nature.com
The folding of transmembrane proteins into the outer membrane presents formidable
challenges to Gram-negative bacteria. These proteins must migrate from the cytoplasm …

Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins

L Han, J Zheng, Y Wang, X Yang, Y Liu… - Nature structural & …, 2016 - nature.com
In Gram-negative bacteria, the assembly of β-barrel outer-membrane proteins (OMPs)
requires the β-barrel–assembly machinery (BAM) complex. We determined the crystal …

Membrane protein insertion through a mitochondrial β-barrel gate

AIC Höhr, C Lindau, C Wirth, J Qiu, DA Stroud, S Kutik… - Science, 2018 - science.org
INTRODUCTION The outer membranes of Gram-negative bacteria, mitochondria, and
chloroplasts characteristically contain β-barrel membrane proteins. These proteins contain …

[HTML][HTML] Dissecting membrane insertion of mitochondrial β-barrel proteins

S Kutik, D Stojanovski, L Becker, T Becker, M Meinecke… - Cell, 2008 - cell.com
Communication of mitochondria with the rest of the cell requires β-barrel proteins of the
outer membrane. All β-barrel proteins are synthesized as precursors in the cytosol and …

Contact‐dependent growth inhibition requires the essential outer membrane protein BamA (YaeT) as the receptor and the inner membrane transport protein AcrB

SK Aoki, JC Malinverni, K Jacoby… - Molecular …, 2008 - Wiley Online Library
Contact‐dependent growth inhibition (CDI) is a phenomenon by which bacterial cell growth
is regulated by direct cell‐to‐cell contact via the CdiA/CdiB two‐partner secretion system …

Structural basis of membrane protein chaperoning through the mitochondrial intermembrane space

K Weinhäupl, C Lindau, A Hessel, Y Wang, C Schütze… - Cell, 2018 - cell.com
The exchange of metabolites between the mitochondrial matrix and the cytosol depends on
β-barrel channels in the outer membrane and α-helical carrier proteins in the inner …

[HTML][HTML] The Bam machine: a molecular cooper

DP Ricci, TJ Silhavy - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2012 - Elsevier
The bacterial outer membrane (OM) is an exceptional biological structure with a unique
composition that contributes significantly to the resiliency of Gram-negative bacteria. Since …

Monitoring the antibiotic darobactin modulating the β-barrel assembly factor BamA

N Ritzmann, S Manioglu, S Hiller, DJ Müller - Structure, 2022 - cell.com
The β-barrel assembly machinery (BAM) complex is an essential component of Escherichia
coli that inserts and folds outer membrane proteins (OMPs). The natural antibiotic compound …

Biogenesis of β-barrel membrane proteins in bacteria and eukaryotes: evolutionary conservation and divergence

DM Walther, D Rapaport, J Tommassen - Cellular and Molecular Life …, 2009 - Springer
Membrane-embedded β-barrel proteins span the membrane via multiple amphipathic β-
strands arranged in a cylindrical shape. These proteins are found in the outer membranes of …