Potent suppressive effects of 1-piperidinylimidazole based novel P2X7 receptor antagonists on cancer cell migration and invasion
JH Park, DR Williams, JH Lee, SD Lee… - Journal of Medicinal …, 2016 - ACS Publications
The P2X7 receptor (P2X7R) has been reported as a key mediator in inflammatory processes
and cancer invasion/metastasis. In this study, we report the discovery of novel P2X7R …
and cancer invasion/metastasis. In this study, we report the discovery of novel P2X7R …
Discovery of Novel 2,5-Dioxoimidazolidine-Based P2X7 Receptor Antagonists as Constrained Analogues of KN62
JH Park, GE Lee, SD Lee, TT Hien, S Kim… - Journal of medicinal …, 2015 - ACS Publications
Novel 2, 5-dioxoimidazolidine-based conformationally constrained analogues of KN62 (1)
were developed as P2X7 receptor (P2X7R) antagonists using a rigidification strategy of the …
were developed as P2X7 receptor (P2X7R) antagonists using a rigidification strategy of the …
Synthesis and structure-activity relationships of quinolinone and quinoline-based P2X7 receptor antagonists and their anti-sphere formation activities in glioblastoma …
Screening a compound library of quinolinone derivatives identified compound 11a as a new
P2X7 receptor antagonist. To optimize its activity, we assessed structure-activity …
P2X7 receptor antagonist. To optimize its activity, we assessed structure-activity …
Atypical P2X7 receptor pharmacology in two human osteoblast‐like cell lines
SM Alqallaf, BAJ Evans, EJ Kidd - British journal of …, 2009 - Wiley Online Library
Background and purpose: The expression and function of P2X7 receptors in osteoclasts is
well established, but less is known about their role in osteoblast‐like cells. A study in P2X7 …
well established, but less is known about their role in osteoblast‐like cells. A study in P2X7 …
Combinatorial Library Synthesis and Biological Evaluation of Pyrazolo[4,3‐e][1,4]diazepine as a Potential Privileged Structure
JY Lee, YC Kim - ChemMedChem: Chemistry Enabling Drug …, 2009 - Wiley Online Library
A privileged structure: A library of tetrahydro‐1, 4‐pyrazolo‐diazepin‐8 (2H)‐ones was
designed and synthesized to probe the privileged nature of the scaffold. The design strategy …
designed and synthesized to probe the privileged nature of the scaffold. The design strategy …
[HTML][HTML] Silencing P2X7 receptor downregulates the expression of TCP-1 involved in lymphoma lymphatic metastasis
X Jiang, W Mao, Z Yang, J Zeng, Y Zhang, Y Song… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abstract P2X 7 R is an ATP-gated cation channel that participates in cell proliferation and
apoptosis. TCP-1 assists with the protein folding. According to our previous research, the …
apoptosis. TCP-1 assists with the protein folding. According to our previous research, the …
Characterization of protoberberine analogs employed as novel human P2X7 receptor antagonists
The P2X7 receptor (P2X7R), a member of the ATP-gated ion channel family, is regarded as
a promising target for therapy of immune-related diseases including rheumatoid arthritis and …
a promising target for therapy of immune-related diseases including rheumatoid arthritis and …