DNA is vulnerable to damage resulting from endogenous metabolites, environmental and
dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics …

Telomeres progressively shorten throughout life. A hallmark of advanced malignancies is
the ability for continuous cell divisions that almost universally correlates with the stabilization …

Cellular senescence is an important factor in aging and many age-related diseases, but
understanding its role in health is challenging due to the lack of exclusive or universal …

Cellular senescence is a fundamental mechanism by which cells remain metabolically
active yet cease dividing and undergo distinct phenotypic alterations, including upregulation …

Cellular metabolism and environmental interactions generate molecular damage affecting
all levels of biological organization. Accumulation of this damage over time is thought to …

For most species, aging promotes a host of degenerative pathologies that are characterized
by debilitating losses of tissue or cellular function. However, especially among vertebrates …

The genome is constantly attacked by genotoxic insults. DNA damage has long been
established as a cause of cancer development through its mutagenic consequences …

Aging is the strongest risk factor for Alzheimer's disease (AD), although the underlying
mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac …

Cellular senescence is a potent tumor-suppressive mechanism that arrests cell proliferation
and has been linked to aging. However, studies of senescence have been impeded by the …

The strengths and limitations of the major methods developed to measure telomere lengths
(TLs) in cells and tissues are presented in this review. These include Q-PCR (Q uantitative P …