Mucosal T-cell responses to chronic viral infections: Implications for vaccine design

M Al-Talib, S Dimonte, IR Humphreys - Cellular & Molecular …, 2024 - nature.com
Mucosal surfaces that line the respiratory, gastrointestinal and genitourinary tracts are the
major interfaces between the immune system and the environment. Their unique …

Recent advancements in poor graft function following hematopoietic stem cell transplantation

Y Man, Z Lu, X Yao, Y Gong, T Yang… - Frontiers in …, 2022 - frontiersin.org
Poor graft function (PGF) is a life-threatening complication that occurs after transplantation
and has a poor prognosis. With the rapid development of haploidentical hematopoietic stem …

Extended-duration letermovir prophylaxis for cytomegalovirus infection after cord blood transplantation in adults

I Politikos, C Lau, SM Devlin, S Quach, A Lin… - Blood …, 2022 - ashpublications.org
Cord blood transplantation (CBT) can be complicated by a high incidence of clinically
significant cytomegalovirus infection (csCMVi). We have investigated the efficacy of …

Immunoprofiling reveals cell subsets associated with the trajectory of cytomegalovirus reactivation post stem cell transplantation

L Stern, HM McGuire, S Avdic… - Nature …, 2022 - nature.com
Human cytomegalovirus reactivation is a major opportunistic infection after allogeneic
haematopoietic stem cell transplantation and has a complex relationship with post …

CMV reactivation after allogeneic HCT is associated with a reduced risk of relapse in acute lymphoblastic leukemia

Y Akahoshi, H Nakasone, K Takenaka… - Blood …, 2023 - ashpublications.org
Cytomegalovirus reactivation (CMVR) after allogeneic hematopoietic cell transplantation
(HCT) is a frequent complication related to survival outcomes; however, its impact on …

Impact of CMV reactivation on relapse of acute myeloid leukemia after HCT is dependent on disease stage and ATG

AT Turki, N Tsachakis-Mück, S Leserer… - Blood …, 2022 - ashpublications.org
Cytomegalovirus (CMV) reactivation is a frequent complication after allogeneic
hematopoietic cell transplantation (HCT), whose impact on clinical outcome, in particular on …

Immune control of cytomegalovirus reactivation in stem cell transplantation

MA Degli-Esposti, GR Hill - Blood, The Journal of the American …, 2022 - ashpublications.org
The reactivation of viruses from latency after allogeneic stem cell transplantation (SCT)
continues to represent a major clinical challenge requiring sophisticated monitoring …

Early-life thymectomy leads to an increase of granzyme-producing γδ T cells in children with congenital heart disease

A Cramer, T Yang, L Riemann, V Almeida… - Nature …, 2024 - nature.com
Congenital heart disease (CHD) is the most common birth defect in newborns, often
requiring cardiac surgery with concomitant thymectomy that is known to increase disease …

Acute Graft-versus-Host Disease: An Update on New Treatment Options

DA Patel, M Crain, I Pusic, MA Schroeder - Drugs, 2023 - Springer
Acute graft-versus-host disease (GVHD) occurs in approximately 50% of patients and
remains a primary driver of non-relapse and transplant-related mortality. The best treatment …

Cytomegalovirus gastroenteritis in patients with acute graft-versus-host disease

Y Akahoshi, S Kimura, Y Tada, T Matsukawa… - Blood …, 2022 - ashpublications.org
A preemptive strategy has successfully decreased cytomegalovirus (CMV) disease after
allogeneic hematopoietic cell transplantation (HCT). However, some recipients still develop …