Segmentation and genome annotation (SAGA) algorithms are widely used to understand
genome activity and gene regulation. These algorithms take as input epigenomic datasets …

A network, whose nodes are genes and whose directed edges represent positive or
negative influences of a regulatory gene and its targets, is often used as a representation of …

Proper maintenance of epigenetic information after replication is dependent on the rapid
assembly and maturation of chromatin. Chromatin Assembly Complex 1 (CAF-1) is a …

Finding causal relationships among biological entities is a core goal of systems biology. In
molecular biology, causal relationships are often encoded as simple graphs called gene …

In eukaryotic cells, The local chromatin structures play a critical role in regulating all DNA-
mediated events. However, the process of DNA replication is highly disruptive to the …

Somatic DNA mutations play critical roles in human disease, especially during
carcinogenesis and tumor development. Two major sources of mutations are the TG …