The role of matrix composition in the mechanical behavior of bone

M Unal, A Creecy, JS Nyman - Current osteoporosis reports, 2018 - Springer
Abstract Purpose of Review While thinning of the cortices or trabeculae weakens bone, age-
related changes in matrix composition also lower fracture resistance. This review …

50 years of scanning electron microscopy of bone—a comprehensive overview of the important discoveries made and insights gained into bone material properties in …

FA Shah, K Ruscsák, A Palmquist - Bone research, 2019 - nature.com
Bone is an architecturally complex system that constantly undergoes structural and
functional optimisation through renewal and repair. The scanning electron microscope …

An integrated experimental-computational framework to assess the influence of microstructure and material properties on fracture toughness in clinical specimens of …

A Demirtas, EA Taylor, B Gludovatz, RO Ritchie… - Journal of the …, 2023 - Elsevier
Microstructural and compositional changes that occur due to aging, pathological conditions,
or pharmacological treatments alter cortical bone fracture resistance. However, the relative …

Assessing matrix quality by Raman spectroscopy helps predict fracture toughness of human cortical bone

M Unal, S Uppuganti, S Timur, A Mahadevan-Jansen… - Scientific reports, 2019 - nature.com
Developing clinical tools that assess bone matrix quality could improve the assessment of a
person's fracture risk. To determine whether Raman spectroscopy (RS) has such potential …

Bone collagen network integrity and transverse fracture toughness of human cortical bone

TL Willett, DY Dapaah, S Uppuganti, M Granke… - Bone, 2019 - Elsevier
Greater understanding of the determinants of skeletal fragility is highly sought due to the
great burden that bone affecting diseases and fractures have on economies, societies and …

Fracture behavior of human cortical bone: Role of advanced glycation end-products and microstructural features

E Maghami, TO Josephson, JP Moore, T Rezaee… - Journal of …, 2021 - Elsevier
Diabetes is associated with increased fracture risk in human bone, especially in the elderly
population. In the present study, we investigate how simulated advanced glycation end …

A review on experimental and numerical investigations of cortical bone fracture

A Kumar, R Ghosh - … , Part H: Journal of Engineering in …, 2022 - journals.sagepub.com
This paper comprehensively reviews the various experimental and numerical techniques,
which were considered to determine the fracture characteristics of the cortical bone. This …

Fracture toughness: bridging the gap between hip fracture and fracture risk assessment

D Dapaah, DR Martel, F Iranmanesh… - Current Osteoporosis …, 2023 - Springer
Abstract Purpose of Review This review surveys recent literature related to cortical bone
fracture mechanics and its application towards understanding bone fragility and hip …

Crack propagation in cortical bone is affected by the characteristics of the cement line: a parameter study using an XFEM interface damage model

A Gustafsson, M Wallin, H Khayyeri… - … and modeling in …, 2019 - Springer
Bulk properties of cortical bone have been well characterized experimentally, and potent
toughening mechanisms, eg, crack deflections, have been identified at the microscale …

Effect of ageing on microstructure and fracture behavior of cortical bone as determined by experiment and Extended Finite Element Method (XFEM)

RN Yadav, P Uniyal, P Sihota, S Kumar… - Medical Engineering & …, 2021 - Elsevier
Bone fracture is a severe health concern; therefore, understanding the causes of bone
fracture are crucial. This paper investigates the microstructure and fracture behaviour of …