1-Isoindolinone scaffold-based natural products with a promising diverse bioactivity
SP Upadhyay, P Thapa, R Sharma, M Sharma - Fitoterapia, 2020 - Elsevier
Abstract Isoindolin-1-one or 1-isoindolinone framework is referred to phthalimidines or
benzo fused γ-lactams of the corresponding γ-amino carboxylic acids and has been of prime …
benzo fused γ-lactams of the corresponding γ-amino carboxylic acids and has been of prime …
Recent efforts in the discovery of urease inhibitor identifications
WQ Song, ML Liu, SY Li, ZP Xiao - Current Topics in Medicinal …, 2022 - ingentaconnect.com
Urease is an attractive drug target for designing anti-infective agents against pathogens
such as Helicobacter pylori, Proteus mirabilis, and Ureaplasma urealyticum. In the past …
such as Helicobacter pylori, Proteus mirabilis, and Ureaplasma urealyticum. In the past …
New isoindole‐1, 3‐dione substituted sulfonamides as potent inhibitors of carbonic anhydrase and acetylcholinesterase: Design, synthesis, and biological evaluation
Herein, a series of isoindole‐1, 3‐dione substituted sulfonamide derivatives (3, 4 a–k) were
designed, synthesized, and biologically evaluated, as inhibitors of carbonic anhydrase (CA) …
designed, synthesized, and biologically evaluated, as inhibitors of carbonic anhydrase (CA) …
Isoindolin-1-ones from the stems of Nicotiana tabacum and their antiviral activities
GY Yang, JM Dai, ZJ Li, J Wang, FX Yang, X Liu… - Archives of Pharmacal …, 2022 - Springer
In previous studies, several isoindolin-1-one analogs that exhibited significant anti-tobacco
mosaic virus (anti-TMV) activities were isolated from Nicotiana tabacum. Since gene-editing …
mosaic virus (anti-TMV) activities were isolated from Nicotiana tabacum. Since gene-editing …
Novel thiobarbiturates as potent urease inhibitors with potential antibacterial activity: Design, synthesis, radiolabeling and biodistribution study
Urease enzyme is a virulence factor that helps in colonization and maintenance of highly
pathogenic bacteria in human. Hence, the inhibition of urease enzymes is well-established …
pathogenic bacteria in human. Hence, the inhibition of urease enzymes is well-established …
Flavonoid analogues as urease inhibitors: Synthesis, biological evaluation, molecular docking studies and in-silico ADME evaluation
H Liu, Y Wang, M Lv, Y Luo, BM Liu, Y Huang… - Bioorganic …, 2020 - Elsevier
A series of novel flavonoid analogues were designed and synthesized. The aimed
compounds for urease inhibitory activities were clearly superior to the control drug thiourea …
compounds for urease inhibitory activities were clearly superior to the control drug thiourea …
Asymmetric cascade Aza-Henry/lactamization reaction in the highly enantioselective organocatalytic synthesis of 3-(nitromethyl) isoindolin-1-ones from α-amido …
The asymmetric synthesis of novel 3-substituted isoindolinones is herein reported. A new
cascade reaction was developed that consisted of the asymmetric nitro-Mannich reaction of …
cascade reaction was developed that consisted of the asymmetric nitro-Mannich reaction of …
Synthesis, molecular docking, and biological evaluation of nitroimidazole derivatives as potent urease inhibitors
M Talebi, E Hamidian, F Niasari-Naslaji… - Medicinal Chemistry …, 2021 - Springer
The objective of this study was to design new nitroimidazole-based derivatives as strong
urease inhibitors for the treatment of H. pylori infections. New series of nitroimidazole …
urease inhibitors for the treatment of H. pylori infections. New series of nitroimidazole …
Isoindolin-1-ones fused to barbiturates: from design and molecular docking to synthesis and urease inhibitory evaluation
Helicobacter pylori-induced ulcers and gastric cancer have been one of the main obstacles
that the human community has ever struggled with, especially in recent decades. Several …
that the human community has ever struggled with, especially in recent decades. Several …
Design, synthesis, and in silico studies of tetrahydropyrimidine analogs as urease enzyme inhibitors
N Ahangarzadeh, N Shakour… - Archiv der …, 2022 - Wiley Online Library
The urease enzyme, a metalloenzyme having Ni2+ ions, is recognized in some bacteria,
fungi, and plants. Particularly, it is vital to the progress of infections induced by pathogenic …
fungi, and plants. Particularly, it is vital to the progress of infections induced by pathogenic …