[HTML][HTML] Ebola virus glycoprotein with increased infectivity dominated the 2013–2016 epidemic
The magnitude of the 2013–2016 Ebola virus disease (EVD) epidemic enabled an
unprecedented number of viral mutations to occur over successive human-to-human …
unprecedented number of viral mutations to occur over successive human-to-human …
Integration of global analyses of host molecular responses with clinical data to evaluate pathogenesis and advance therapies for emerging and re-emerging viral …
SD Falcinelli, DS Chertow… - ACS infectious diseases, 2016 - ACS Publications
Outbreaks associated with emerging and re-emerging viral pathogens continue to increase
in frequency and are associated with an increasing burden to global health. In light of this …
in frequency and are associated with an increasing burden to global health. In light of this …
Recently identified mutations in the Ebola virus-Makona genome do not alter pathogenicity in animal models
A Marzi, S Chadinah, E Haddock, F Feldmann, N Arndt… - Cell reports, 2018 - cell.com
Ebola virus (EBOV), isolate Makona, the causative agent of the West African EBOV
epidemic, has been the subject of numerous investigations to determine the genetic diversity …
epidemic, has been the subject of numerous investigations to determine the genetic diversity …
Innate immune responses of bat and human cells to filoviruses: commonalities and distinctions
IV Kuzmin, TM Schwarz, PA Ilinykh, I Jordan… - Journal of …, 2017 - Am Soc Microbiol
ABSTRACT Marburg (MARV) and Ebola (EBOV) viruses are zoonotic pathogens that cause
severe hemorrhagic fever in humans. The natural reservoir of MARV is the Egyptian rousette …
severe hemorrhagic fever in humans. The natural reservoir of MARV is the Egyptian rousette …
West Africa 2013 Ebola: from virus outbreak to humanitarian crisis
DG Bausch - Marburg-and Ebolaviruses: From Ecosystems to …, 2017 - Springer
The 2013 outbreak of Ebola virus disease (EVD) in West Africa constituted a major
humanitarian crisis. The outbreak numbered over 28,500 cases, more than 10 times the …
humanitarian crisis. The outbreak numbered over 28,500 cases, more than 10 times the …
[HTML][HTML] Perspectives on West Africa Ebola virus disease outbreak, 2013–2016
JR Spengler, ED Ervin, JS Towner… - Emerging infectious …, 2016 - ncbi.nlm.nih.gov
The variety of factors that contributed to the initial undetected spread of Ebola virus disease
in West Africa during 2013–2016 and the difficulty controlling the outbreak once the etiology …
in West Africa during 2013–2016 and the difficulty controlling the outbreak once the etiology …
[HTML][HTML] Novel activities by ebolavirus and marburgvirus interferon antagonists revealed using a standardized in vitro reporter system
JC Guito, CG Albariño, AK Chakrabarti, JS Towner - Virology, 2017 - Elsevier
Filoviruses are highly lethal in humans and nonhuman primates, likely due to potent
antagonism of host interferon (IFN) responses early in infection. Filoviral protein VP35 is …
antagonism of host interferon (IFN) responses early in infection. Filoviral protein VP35 is …
The Ebola virus VP35 protein binds viral immunostimulatory and host RNAs identified through deep sequencing
KA Dilley, AA Voorhies, P Luthra, V Puri, TB Stockwell… - PLoS …, 2017 - journals.plos.org
Ebola virus and Marburg virus are members of the Filovirdae family and causative agents of
hemorrhagic fever with high fatality rates in humans. Filovirus virulence is partially attributed …
hemorrhagic fever with high fatality rates in humans. Filovirus virulence is partially attributed …
The integrity of the YxxL motif of Ebola virus VP24 is important for the transport of nucleocapsid-like structures and for the regulation of viral RNA synthesis
Y Takamatsu, L Kolesnikova, M Schauflinger… - Journal of …, 2020 - Am Soc Microbiol
While it is well appreciated that late domains in the viral matrix proteins are crucial to
mediate efficient virus budding, little is known about roles of late domains in the viral …
mediate efficient virus budding, little is known about roles of late domains in the viral …
VP24 matrix proteins of eight filoviruses downregulate innate immune response by inhibiting the interferon-induced pathway
H Khan, L Tripathi, P Kolehmainen… - Journal of General …, 2023 - microbiologyresearch.org
Filoviruses encode viral protein 24 (VP24) which effectively inhibit the innate immune
responses in infected cells. Here we systematically analysed the effects of nine mammalian …
responses in infected cells. Here we systematically analysed the effects of nine mammalian …