The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Tissue inhibitors of metalloproteinases (TIMPs), which inhibit matrix metalloproteinases
(MMPs) as well as the closely related, a disintegrin and metalloproteinases (ADAMs) and …

Little is known about the relative importance of monocyte and tissue-resident macrophages
in the development of lung fibrosis. We show that specific genetic deletion of monocyte …

Aortic aneurysm is an asymptomatic disease with dire outcomes if undiagnosed. Aortic
aneurysm rupture is a significant cause of death worldwide. To date, surgical repair or …

Cardiovascular disease is a leading cause of death, and translational research is needed to
understand better mechanisms whereby the left ventricle responds to injury. Mouse models …

Cardiovascular disease is a leading cause of death worldwide and there is a pressing need
for new therapeutic strategies to treat such conditions. The risk of developing cardiovascular …

Tissue inhibitor of metalloproteinase 3 (TIMP3) is unique among the four TIMPs due to its
extracellular matrix (ECM)-binding property and broad range of inhibitory substrates that …

Myocardial fibrosis is excess accumulation of the extracellular matrix fibrillar collagens.
Fibrosis is a key feature of various cardiomyopathies and compromises cardiac systolic and …

The apelin pathway has emerged as a critical regulator of cardiovascular homeostasis and
disease. However, the exact role of pyr1-apelin-13 in angiotensin (Ang) II–mediated heart …

Cardiovascular complications contribute to the major mortality and morbidity in type 2
diabetes. Diabetic cardiomyopathy (DCM) is increasingly recognized as an important cause …