TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially
restricted generation of bioactive TGF-β from latent stores requires the cooperation of …

Renal tubules are the major component of the kidney and are vulnerable to a variety of
injuries including hypoxia, proteinuria, toxins, metabolic disorders, and senescence. It has …

Transforming growth factor-β (TGF-β) is the primary factor that drives fibrosis in most, if not
all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its …

Tissue damage and inflammation are important triggers for regeneration and fibrosis. Tissue
damage not only induces inflammation in general, it also determines the type and …

Epithelial-mesenchymal transition (EMT) is described as the process in which injured renal
tubular epithelial cells undergo a phenotype change, acquiring mesenchymal characteristics …

Kidney fibrosis is marked by an epithelial-to-mesenchymal transition (EMT) of tubular
epithelial cells (TECs). Here we find that, during renal fibrosis, TECs acquire a partial EMT …

Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

Chronic kidney disease (CKD) has emerged as a major cause of morbidity and mortality
worldwide. Interstitial fibrosis, glomerulosclerosis and inflammation play the central role in …

Acute kidney injury is an increasingly common complication of hospital admission and is
associated with high levels of morbidity and mortality. A hypotensive, septic, or toxic insult …

TGF-β (transforming growth factor-β) is well identified as a central mediator in renal fibrosis.
TGF-β initiates canonical and non-canonical pathways to exert multiple biological effects …