Hepatocellular carcinoma (HCC) poses a heavy burden on human health with high
morbidity and mortality rates. Systematic therapy is crucial for advanced and mid-term HCC …

Background Synovial fibroblasts in rheumatoid arthritis (RAFLS) exhibit a pathological
aberration of glycolysis and glutaminolysis. Henceforth, we aimed to investigate if dual …

The homeostatic oxygen sensing system (HOSS) optimizes systemic oxygen delivery.
Specialized tissues utilize a conserved mitochondrial sensor, often involving NDUFS2 in …

Tumor development and metastasis are closely related to the complexity of the metabolism
network. Recently, metabolism reprogramming strategies have attracted much attention in …

Chloroethylnitrosoureas (CENUs) are bifunctional antitumor alkylating agents, which exert
their antitumor activity through inducing the formation of dG-dC interstrand crosslinks (ICLs) …

Abstract Bromopyruvate (3-BrPA) is a glycolysis inhibitor that has been reported to have a
strong anti-tumour effect in many human tumours. Several studies have reported that 3-BrPA …

Metabolic reprogramming of tumour cells sustains cancer progression. Similar to other
cancer cells, glioblastoma cells exhibit an increased glycolytic flow, which encourages the …

High-grade gliomas are among the deadliest of all cancers despite standard treatments, and
new therapeutic strategies are needed to improve patient outcome. Targeting the altered …

Background Direct 3-bromopyruvate chemotherapy often causes side effects. We thus
aimed to construct and evaluate folic acid-modified 3-bromopyruvate liquid crystalline …

摘要肿瘤通过葡萄糖代谢重组为自身提供物质与能量, 满足其快速增长所需.
研究表明参与葡萄糖代谢过程中的多种代谢酶及信号分子在肿瘤发生, 发展中发挥着重要作用 …