RNA ac4C modification is a novel and rare chemical modification observed in mRNA.
Traditional biochemical studies had primarily associated ac4C modification with tRNA and …

RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …

Aberrant RNA modifications are frequently associated with cancers, while the underlying
mechanisms and clinical significance remain poorly understood. Here, we find that the ac4C …

Abstract NAT10-catalyzed N4-acetylcytidine (ac4C) has emerged as a vital post-
transcriptional modulator on the coding transcriptome by promoting mRNA stability …

In mammals, the production of mature oocytes necessitates rigorous regulation of the
discontinuous meiotic cell-cycle progression at both the transcriptional and post …

Anti‐angiogenic therapy has long been considered a promising strategy for solid cancers.
Intrinsic resistance to hypoxia is a major cause for the failure of anti‐angiogenic therapy, but …

The oldest known highly conserved modification of RNA, N4-acetylcytidine, is widely
distributed from archaea to eukaryotes and acts as a posttranscriptional chemical …

Abstract N4-acetylcytidine (ac4C) is a vital constituent of the epitranscriptome and plays a
crucial role in the regulation of mRNA expression. Numerous studies have established …

When DNA interstrand crosslink lesions occur, a core complex of Fanconi anemia proteins
promotes the ubiquitination of FANCD2 and FANCI, which recruit downstream factors to …

Abstract N4-acetylcytidine (ac4C) is a lately discovered nucleotide modification that has
been shown to be closely implicated in cancer. N-acetyltransferase10 (NAT10) acts as an …