Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for
harnessing the potential of a patient's own immune system to eliminate tumor cells in …

Accumulating evidence indicates that the innate and adaptive immune systems make a
crucial contribution to the antitumour effects of conventional chemotherapy-based and …

Aims Although macrophage phenotypes have been well studied in the myocardial infarction
(MI) setting, this study investigated temporal neutrophil polarization and activation …

Heat-shock proteins (HSPs) are the most abundant and ubiquitous soluble intracellular
proteins. In single-cell organisms, invertebrates and vertebrates, they perform a multitude of …

Organismal homeostasis depends on an intricate balance between cell death and renewal.
Early pathologists recognized that this balance could be disrupted by the extensive damage …

Human heat-shock protein (HSP) 70 activates innate immune cells and hence requires no
additional adjuvants to render bound peptides immunogenic. Here we tested the …

Heat shock proteins are abundant soluble intracellular proteins, present in all cells.
Members of the heat shock protein family bind peptides including antigenic peptides …

Heat shock proteins (HSPs) such as HSP 60 (Hsp60), Hsp70, Hsp90, and gp96, have been
reported to play important roles in antigen presentation and cross-presentation, activation of …

Natural killer (NK) cells and dendritic cells (DCs) are two types of specialized cell of the
innate immune system, the reciprocal interaction of which results in a potent, activating cross …

Peptides bound or linked to heat-shock proteins (HSPs) of microbial or mammalian origin
have been shown to elicit potent antigen-specific immunity. Some members of the HSP …