Simple Summary Organ preservation strategies can be offered to patients with rectal cancer
that show a strong response to preoperative treatment in order to avoid major surgery …

Rectal cancer (RC) is the third most frequently diagnosed cancer worldwide, and the status
of its circumferential resection margin (CRM) is of paramount significance for treatment …

Importance In March 2023, the National Comprehensive Cancer Network endorsed watch
and wait for those with complete clinical response to total neoadjuvant therapy. Neoadjuvant …

In the past 40 years, the treatment of locally advanced rectal cancer has evolved with the
addition of radiotherapy or chemoradiotherapy and providing (neo) adjuvant systemic …

Objectives Partial or total resistance to preoperative chemoradiotherapy occurs in more than
half of locally advanced rectal cancer patients. Several novel or repurposed drugs have …

Background Older patients with early-stage rectal cancer are under-represented in clinical
trials and, therefore, little high-quality data are available to guide treatment in this patient …

Introduction Multimodality treatment for locally advanced rectal cancer (LARC) can include
long-course radiotherapy (LCRT) or short course radiotherapy (SCRT). Nonoperative …

Introduction Patients with early-stage and locally advanced rectal cancer are often treated
with neoadjuvant therapy followed by surgery or watch and wait. This study evaluated the …

Purpose Pre-treatment knowledge of the anticipated response of rectal tumors to
neoadjuvant chemoradiotherapy (CRT) could help to further optimize the treatment. Van …

Background In rectal cancer, watch and wait for patients with a cCR after neoadjuvant
treatment has an established evidence base. However, there is a lack of consensus on the …