ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1)
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …

1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …

Tacrolimus (FK506) and cyclosporine (cyclosporin A, CsA) are cornerstone
immunosuppressive agents administered to solid organ transplant recipients to prevent and …

Introduction: Human ATP-binding cassette (ABC) transporters act as translocators of
numerous substrates across extracellular and intracellular membranes, thereby contributing …

Abstract P-glycoprotein (ABCB1, MDR1) belongs to the ABC transporter family transporting
a wide range of drugs and xenobiotics from intra-to extracellular at many biological …

Introduction Interindividual differences in drug response are a frequent clinical challenge
partly due to variation in pharmacokinetics. ATP-binding cassette (ABC) transporters are …

One of the primary diseases that cause death worldwide is cancer. Cancer cells can be
intrinsically resistant or acquire resistance to therapies and drugs used for cancer treatment …

Aims: This prospective study investigated the effect of genetic polymorphisms in a
biotransformation enzyme (CYP3A5) and a transporter protein (ABCB1) on tacrolimus (Tac) …

The membrane transporter P-glycoprotein, encoded by the ABCB1 gene, influences the
pharmacokinetics of anti-cancer drugs. We hypothesized that variants of ABCB1 affect …

Objective The expression on lymphocytes of P-glycoprotein, an efflux transporter encoded
by the ABCB1 gene, might influence cyclosporine intracellular concentration. Methods …