Monofluorination of organic compounds: 10 years of innovation

PA Champagne, J Desroches, JD Hamel… - Chemical …, 2015 - ACS Publications
Taking into account the vast arrays of fluorinated motifs known, 11 this review will be limited
to the monofluorination of organic compounds, ie, synthetic methods allowing the …

Introduction of fluorine and fluorine‐containing functional groups

T Liang, CN Neumann, T Ritter - … Chemie International Edition, 2013 - Wiley Online Library
Over the past decade, the most significant, conceptual advances in the field of fluorination
were enabled most prominently by organo‐and transition‐metal catalysis. The most …

Fluorination methods in drug discovery

DE Yerien, S Bonesi, A Postigo - Organic & Biomolecular Chemistry, 2016 - pubs.rsc.org
Fluorination reactions of medicinal and biologically-active compounds will be discussed.
Late stage fluorination strategies of medicinal targets have recently attracted considerable …

The many roles for fluorine in medicinal chemistry

WK Hagmann - Journal of medicinal chemistry, 2008 - ACS Publications
Drug candidates with one or more fluorines have become commonplace. The special nature
of fluorine imparts a variety of properties to certain medicines, including enhanced binding …

Reactive p-block cations stabilized by weakly coordinating anions

TA Engesser, MR Lichtenthaler, M Schleep… - Chemical Society …, 2016 - pubs.rsc.org
The chemistry of the p-block elements is a huge playground for fundamental and applied
work. With their bonding from electron deficient to hypercoordinate and formally hypervalent …

Key green chemistry research areas—a perspective from pharmaceutical manufacturers

DJC Constable, PJ Dunn, JD Hayler, GR Humphrey… - Green …, 2007 - pubs.rsc.org
In 2005, the ACS Green Chemistry Institute (GCI) and the global pharmaceutical
corporations developed the ACS GCI Pharmaceutical Roundtable to encourage the …

Asymmetric fluorination, trifluoromethylation, and perfluoroalkylation reactions

JA Ma, D Cahard - Chemical reviews, 2004 - ACS Publications
Very few fields in chemistry have shown such a considerable interest as fluoroorganic
chemistry. Fluorine is perhaps the element that has experienced the greatest recent interest …

Hypervalent iodine (III) fluorinations of alkenes and diazo compounds: new opportunities in fluorination chemistry

SV Kohlhepp, T Gulder - Chemical Society Reviews, 2016 - pubs.rsc.org
The fluorination of organic molecules is a rapidly evolving and exciting field in synthesis,
which still poses huge challenges despite the advances made in the past decades …

Silver-catalyzed decarboxylative fluorination of aliphatic carboxylic acids in aqueous solution

F Yin, Z Wang, Z Li, C Li - Journal of the American Chemical …, 2012 - ACS Publications
Although fluorinated compounds have found widespread applications in the chemical and
materials industries, general and site-specific C (sp3)–F bond formations are still a …

Einführung von Fluor und fluorhaltigen funktionellen Gruppen

T Liang, CN Neumann, T Ritter - Angewandte Chemie, 2013 - Wiley Online Library
Die wichtigsten konzeptionellen Fortschritt auf dem Gebiet der Fluorierungen der letzten
zehn Jahre wurden durch die Organo‐und Übergangsmetallkatalyse ermöglicht. Die …