Medical device related infections are a significant and growing source of morbidity and
mortality. Biofilm formation is a common feature of medical device infections that is not …

We presented an antibiotic-loaded γ-cyclodextrin metal-organic framework that delivered
antibiotics suitable for the treatment of bacterial infections. The γ-cyclodextrin metal-organic …

In the last decade, a variety of methods for fabrication of three-dimensional biomimetic
scaffolds based on hydrogels have been developed for tissue engineering. However, many …

Extremity reconstruction surgery is increasingly performed rather than amputation for
patients with large-segment pathologic bone loss. Debate persists as to the optimal void …

This research aimed to chemically synthesize four different sized hydroxyapatite (HA)
compound nanoparticles, then coating them with trehalose sugar. After that, a drug release …

Nearly 1.3 million total joint replacement procedures are performed in the United States
annually, with numbers projected to rise exponentially in the coming decades. Although …

Infection remains a significant problem associated with biomedical implants and orthopedic
surgeries, especially in revision total joint replacements. Recent advances in antibiotic …

From traditional approaches of employing bulk materials to the new generation of bioactive
coated implants, the design of such medical tools is being directed towards the …

Implant-associated infections remain a significant source of morbidity in the clinic. Systemic
administration of antibiotics is often ineffective, due in part to limited vascularization of the …

Osteomyelitis is a frequent complication of diabetic foot ulcers and/or diabetic foot infection.
It is defined as an infection of bone tissue and it is an aggravated condition in diabetic …