Transition-metal catalysis has been consequential in enabling carbon–heteroatom bond-
forming reactions. Recent breakthroughs in Ni-catalyzed cross-couplings have offered …

Unimolecular fragment coupling (UFC) is defined as a reaction format, wherein atom (s)
located in the middle of a molecule are extruded, and the remaining fragments are coupled …

Removing the nitrogen atom from secondary amines while simultaneously linking the
remaining fragments is a powerful form of late-stage skeletal editing. Here, we report its use …

Classical metalation reactions such as the metal-halogen exchange have had a
transformative impact on organic synthesis owing to their broad applicability in building …

Advances in site-selective molecular editing have enabled structural modification on
complex molecules. However, thus far, their applications have been restricted to C–H …

The synthesis of pyridines from dinitrogen in homogeneous solution is known to be
challenging considering that an N2 cleavage step needs to be combined with two N–C …

We report herein the catalytic conversion of allylic esters into the corresponding ketones by
the formal deletion of an oxygen atom. The key to the success of the reaction is the dual use …

Atom-swap chemistry could aid drug discovery Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

We report a C–N cross-coupling reaction of weakly nucleophilic N-arylsulfonamides and aryl
bromides to access N, N-diarylsulfonamides using Ni (cod)(DQ) as a catalyst without …

The skeletal editing of dibenzolactones to fluorenes by Ni-or Pd-catalyzed decarboxylation
is reported. In contrast to previously reported intramolecular decarboxylative couplings …