Advances in areas such as data analytics, genomics, and imaging have revealed individual patient complexities and exposed the inherent limitations of generic therapies for patient …
Background The effects of pharmacological blood pressure lowering at normal or high- normal blood pressure ranges in people with or without pre-existing cardiovascular disease …
Importance Patent foramen ovale (PFO)–associated strokes comprise approximately 10% of ischemic strokes in adults aged 18 to 60 years. While device closure decreases stroke …
Aims The aim of this study was to derive and validate the SCORE2-Older Persons (SCORE2- OP) risk model to estimate 5-and 10-year risk of cardiovascular disease (CVD) in individuals …
Machine learning methods, combined with large electronic health databases, could enable a personalised approach to medicine through improved diagnosis and prediction of …
Heterogeneity of treatment effect (HTE) refers to the nonrandom variation in the magnitude or direction of a treatment effect across levels of a covariate, as measured on a selected …
K Takahashi, PW Serruys, V Fuster, ME Farkouh… - The Lancet, 2020 - thelancet.com
Background Randomised controlled trials are considered the gold standard for testing the efficacy of novel therapeutic interventions, and typically report the average treatment effect …
L Bickman - Administration and Policy in Mental Health and Mental …, 2020 - Springer
This conceptual paper describes the current state of mental health services, identifies critical problems, and suggests how to solve them. I focus on the potential contributions of artificial …
In the 20th century, evidence-based medicine has put clinical practice on much more solid ground. For instance, randomized clinical trials have provided strong evidence on useful …