Over the past decade, substantial progress has been made in the discovery of alleles
contributing to the risk of coronary artery disease. In addition to providing causal insights into …

Advances in areas such as data analytics, genomics, and imaging have revealed individual
patient complexities and exposed the inherent limitations of generic therapies for patient …

Background The effects of pharmacological blood pressure lowering at normal or high-
normal blood pressure ranges in people with or without pre-existing cardiovascular disease …

Importance Patent foramen ovale (PFO)–associated strokes comprise approximately 10% of
ischemic strokes in adults aged 18 to 60 years. While device closure decreases stroke …

Aims The aim of this study was to derive and validate the SCORE2-Older Persons (SCORE2-
OP) risk model to estimate 5-and 10-year risk of cardiovascular disease (CVD) in individuals …

Machine learning methods, combined with large electronic health databases, could enable
a personalised approach to medicine through improved diagnosis and prediction of …

Heterogeneity of treatment effect (HTE) refers to the nonrandom variation in the magnitude
or direction of a treatment effect across levels of a covariate, as measured on a selected …

Background Randomised controlled trials are considered the gold standard for testing the
efficacy of novel therapeutic interventions, and typically report the average treatment effect …

This conceptual paper describes the current state of mental health services, identifies critical
problems, and suggests how to solve them. I focus on the potential contributions of artificial …

In the 20th century, evidence-based medicine has put clinical practice on much more solid
ground. For instance, randomized clinical trials have provided strong evidence on useful …