[HTML][HTML] Neural contributions to muscle fatigue: from the brain to the muscle and back again

JL Taylor, M Amann, J Duchateau… - Medicine and science …, 2016 - ncbi.nlm.nih.gov
During exercise, there is a progressive reduction in the ability to produce muscle forces.
Processes within the nervous system, as well as within the muscles contribute to this fatigue …

Rate coding and the control of muscle force

RM Enoka, J Duchateau - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
The force exerted by a muscle during a voluntary contraction depends on the number of
motor units recruited for the action and the rates at which they discharge action potentials …

Nonlinear input-output functions of motoneurons

MD Binder, RK Powers, CJ Heckman - Physiology, 2020 - journals.physiology.org
All movements are generated by the activation of motoneurons, and hence their input-output
properties define the final step in processing of all motor commands. A major challenge to …

A motor unit-based model of muscle fatigue

JR Potvin, AJ Fuglevand - PLoS computational biology, 2017 - journals.plos.org
Muscle fatigue is a temporary decline in the force and power capacity of skeletal muscle
resulting from muscle activity. Because control of muscle is realized at the level of the motor …

Distribution of motor unit properties across human muscles

J Duchateau, RM Enoka - Journal of Applied Physiology, 2022 - journals.physiology.org
The purpose of our review was to compare the distribution of motor unit properties across
human muscles of different sizes and recruitment ranges. Although motor units can be …

Physiological validation of the decomposition of surface EMG signals

RM Enoka - Journal of Electromyography and Kinesiology, 2019 - Elsevier
Advances in technology have ushered in a new era in the measurement and interpretation
of surface-recorded electromyographic (EMG) signals. These developments have included …

A geometric approach to quantifying the neuromodulatory effects of persistent inward currents on individual motor unit discharge patterns

JA Beauchamp, GEP Pearcey… - Journal of neural …, 2023 - iopscience.iop.org
Objective. All motor commands flow through motoneurons, which entrain control of their
innervated muscle fibers, forming a motor unit (MU). Owing to the high fidelity of action …

[HTML][HTML] Estimation of self-sustained activity produced by persistent inward currents using firing rate profiles of multiple motor units in humans

B Afsharipour, N Manzur… - Journal of …, 2020 - journals.physiology.org
Persistent inward calcium and sodium currents (IP) activated during motoneuron recruitment
help synaptic inputs maintain self-sustained firing until derecruitment. Here, we estimate the …

The potential for understanding the synaptic organization of human motor commands via the firing patterns of motoneurons

MD Johnson, CK Thompson… - Journal of …, 2017 - journals.physiology.org
Motoneurons are unique in being the only neurons in the CNS whose firing patterns can be
easily recorded in human subjects. This is because of the one-to-one relationship between …

Delayed onset muscle soreness (DOMS): the repeated bout effect and chemotherapy-induced axonopathy may help explain the dying-back mechanism in …

B Sonkodi - Brain sciences, 2021 - mdpi.com
Delayed onset muscle soreness (DOMS) is hypothesized to be caused by glutamate
excitotoxicity-induced acute compression axonopathy of the sensory afferents in the muscle …