Calpain is a ubiquitous calcium-sensitive protease that is essential for normal physiologic
neuronal function. However, alterations in calcium homeostasis lead to persistent …

Multiple sclerosis (MS) is the most common demyelinating and an autoimmune disease of
the central nervous system characterized by immune-mediated myelin and axonal damage …

Background 'Encephalomyelitis disseminata'(multiple sclerosis) and myalgic
encephalomyelitis/chronic fatigue syndrome (ME/CFS) are both classified as diseases of the …

Background and Purpose Dietary indole derivatives, indole-3-carbinol (I3C) and
diindolylmethane (DIM), possess anti-cancer properties and exhibit the characteristics of aryl …

Background Multiple sclerosis (MS) is a chronic immune-mediated disorder of the central
nervous system characterized by demyelination, neuroinflammation, and …

Multiple sclerosis is an autoimmune disease with classical traits of demyelination, axonal
damage, and neurodegeneration. The migration of autoimmune T cells and macrophages …

Multiple sclerosis, the clinical features and pathological correlate for which were first
described by Charcot, is a chronic neuroinflammatory disease with unknown etiology and …

There is evidence that activated immune-inflammatory and oxidative and nitrosative stress
(IO&NS) pathways play a role in the pathophysiology of multiple sclerosis (MS) and …

Gut microbiota has essential roles in the prevention and progression of multiple sclerosis
(MS). The association between the gut microbiota and the central nervous system (CNS) or …

Background Studies have shown that transplantation of bone marrow-derived mesenchymal
stem cells (BMSCs) protects against brain damage. However, the low survival number of …