Generating reactive oxygen species (ROS) is necessary for both physiology and pathology.
An imbalance between endogenous oxidants and antioxidants causes oxidative stress …

Mammalian cells possess a multifaceted antioxidant enzyme system, which includes
superoxide dismutases, catalase, the peroxiredoxin/thioredoxin and the glutathione …

Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality
rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis …

Selenium (Se) is a trace nutrient that promotes human health through its incorporation into
selenoproteins in the form of the redox-active amino acid selenocysteine (Sec). There are 25 …

Incorporation of selenium (Se) atom into small molecules can substantially enhance their
antioxidant, anti-inflammatory, antimutagenic, antitumoral or chemopreventive, antiviral …

Selenoprotein-P (SELENOP) is the main carrier of selenium to target organs and reduces
tissue oxidative stress both directly and by delivering selenium to protective selenoproteins …

Reactive oxygen species and reactive nitrogen species are highly implicated in kidney
injuries that include acute kidney injury, chronic kidney disease, hypertensive nephropathy …

Emerging evidence indicates that the dysregulation of cellular redox homeostasis and
chronic inflammatory processes are implicated in the pathogenesis of kidney and brain …

Although microvascular dysfunction (MVD) has been well characterized in individual organs
as different disease entities, clinical evidence is mounting in support of an underlying …

Ebselen is a synthetic organoselenium radical scavenger compound that possesses
glutathione peroxidase-like activity and its own unique bioactivity by reacting with thiols …