A precision environmental health approach to prevention of human disease

A Baccarelli, DC Dolinoy, CL Walker - Nature Communications, 2023 - nature.com
Human health is determined by the interaction of our environment with the genome,
epigenome, and microbiome, which shape the transcriptomic, proteomic, and metabolomic …

Genomic medicine for kidney disease

EE Groopman, HM Rasouly, AG Gharavi - Nature Reviews Nephrology, 2018 - nature.com
Technologies such as next-generation sequencing and chromosomal microarray have
advanced the understanding of the molecular pathogenesis of a variety of renal disorders …

[HTML][HTML] Recommendations on the use and reporting of race, ethnicity, and ancestry in genetic research: Experiences from the NHLBI TOPMed program

AT Khan, SM Gogarten, CP McHugh, AM Stilp, T Sofer… - Cell genomics, 2022 - cell.com
How race, ethnicity, and ancestry are used in genomic research has wide-ranging
implications for how research is translated into clinical care and incorporated into public …

On the utilization of polygenic risk scores for therapeutic targeting

G Gibson - PLoS genetics, 2019 - journals.plos.org
The promise of personalized genomic medicine is that knowledge of a person's gene
sequences and activity will facilitate more appropriate medical interventions, particularly …

Genomic Essentialism: Its Provenance and Trajectory as an Anticipatory Ethical Concern

M Sabatello, E Juengst - Hastings Center Report, 2019 - Wiley Online Library
Since the inception of large‐scale human genome research, there has been much caution
about the risks of exacerbating a number of socially dangerous attitudes linked to human …

Why does the shift from “personalized medicine” to “precision health” and “wellness genomics” matter?

ET Juengst, ML McGowan - AMA Journal of Ethics, 2018 - journalofethics.ama-assn.org
Why Does the Shift from “Personalized Medicine” to “Precision Health” and “Wellness
Genomics” Matter? | Journal of Ethics | American Medical Association Skip to main content …

Adolescent and parental attitudes about return of genomic research results: focus group findings regarding decisional preferences

ML McGowan, CA Prows… - Journal of Empirical …, 2018 - journals.sagepub.com
Opportunities to participate in genomic sequencing studies, as well as recommendations to
screen for variants in 59 medically actionable genes anytime clinical genomic sequencing is …

DNA-methylation signatures of tobacco smoking in a high cardiovascular risk population: modulation by the Mediterranean diet

R Fernández-Carrión, JV Sorlí, EM Asensio… - International Journal of …, 2023 - mdpi.com
Biomarkers based on DNA methylation are relevant in the field of environmental health for
precision health. Although tobacco smoking is one of the factors with a strong and consistent …

Health equity and implementation science in heart, lung, blood, and sleep-related research: emerging themes from the 2018 Saunders-Watkins Leadership Workshop

MR Sterling, SE Echeverría… - … Quality and Outcomes, 2019 - Am Heart Assoc
Disparities in health outcomes for heart, lung, blood, and sleep-related health conditions are
pervasive in the United States, with an unequal burden experienced among structurally …

The imaginary of precision public health

M Kenney, L Mamo - Medical humanities, 2020 - mh.bmj.com
In recent years, precision medicine has emerged as a charismatic name for a growing
movement to revolutionise biomedicine by bringing genomic knowledge and sequencing to …