Repurposing of drugs: An attractive pharmacological strategy for cancer therapeutics
A Kirtonia, K Gala, SG Fernandes, G Pandya… - Seminars in cancer …, 2021 - Elsevier
Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …
anticipated to rise in the future. The development of novel drugs/agents requires a huge …
Anticancer and antiviral properties of cardiac glycosides: a review to explore the mechanism of actions
Cardiac glycosides (CGs) have a long history of treating cardiac diseases. However, recent
reports have suggested that CGs also possess anticancer and antiviral activities. The …
reports have suggested that CGs also possess anticancer and antiviral activities. The …
Lanatoside C induces G2/M cell cycle arrest and suppresses cancer cell growth by attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways
Cardiac glycosides (CGs) are a diverse family of naturally derived compounds having a
steroid and glycone moiety in their structures. CG molecules inhibit the α-subunit of …
steroid and glycone moiety in their structures. CG molecules inhibit the α-subunit of …
Emergence of cardiac glycosides as potential drugs: Current and future scope for cancer therapeutics
Cardiac glycosides are natural sterols and constitute a group of secondary metabolites
isolated from plants and animals. These cardiotonic agents are well recognized and …
isolated from plants and animals. These cardiotonic agents are well recognized and …
[HTML][HTML] Periplocin exerts antitumor activity by regulating Nrf2-mediated signaling pathway in gemcitabine-resistant pancreatic cancer cells
Although gemcitabine-based chemotherapy is common and effective for pancreatic cancer
(PC), acquired drug resistance is one of the major reasons for treatment failure. Therefore, a …
(PC), acquired drug resistance is one of the major reasons for treatment failure. Therefore, a …
Glycosides from medicinal plants as potential anticancer agents: emerging trends towards future drugs
Background: Cancer continues to be a global burden, despite the advancement of various
technological and pharmaceutical improvements over the past two decades. Methods for …
technological and pharmaceutical improvements over the past two decades. Methods for …
Prospects and therapeutic applications of cardiac glycosides in cancer remediation
Active metabolites from natural sources are the predominant molecular targets in numerous
biological studies owing to their appropriate compatibility with biological systems and …
biological studies owing to their appropriate compatibility with biological systems and …
Digoxin enhances the anticancer effect on non-small cell lung cancer while reducing the cardiotoxicity of adriamycin
Y Wang, Q Ma, S Zhang, H Liu, B Zhao, B Du… - Frontiers in …, 2020 - frontiersin.org
Digoxin is widely used to treat heart failure. Epidemiological studies suggested it might be
used as an anticancer drug or sensitizing agent for cancer therapy. Adriamycin is a …
used as an anticancer drug or sensitizing agent for cancer therapy. Adriamycin is a …
Peruvoside targets apoptosis and autophagy through MAPK Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways in human cancers
Aim To investigate the cytotoxic effect of Peruvoside and mechanism of action in human
cancers. Main methods Cell viability was measured by MTT assay and the cell cycle arrest …
cancers. Main methods Cell viability was measured by MTT assay and the cell cycle arrest …
Modular total synthesis and cell-based anticancer activity evaluation of ouabagenin and other cardiotonic steroids with varying degrees of oxygenation
A Cu (II)-catalyzed diastereoselective Michael/aldol cascade approach is used to
accomplish concise total syntheses of cardiotonic steroids with varying degrees of …
accomplish concise total syntheses of cardiotonic steroids with varying degrees of …