The role of toxins in Clostridium difficile infection

R Chandrasekaran, DB Lacy - FEMS microbiology reviews, 2017 - academic.oup.com
Clostridium difficile is a bacterial pathogen that is the leading cause of nosocomial antibiotic-
associated diarrhea and pseudomembranous colitis worldwide. The incidence, severity …

Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal Effects

S Di Bella, P Ascenzi, S Siarakas, N Petrosillo… - Toxins, 2016 - mdpi.com
Clostridium difficile infection (CDI) has significant clinical impact especially on the elderly
and/or immunocompromised patients. The pathogenicity of Clostridium difficile is mainly …

[HTML][HTML] Curvature, lipid packing, and electrostatics of membrane organelles: defining cellular territories in determining specificity

J Bigay, B Antonny - Developmental cell, 2012 - cell.com
Whereas some rare lipids contribute to the identity of cell organelles, we focus on the
abundant lipids that form the matrix of organelle membranes. Observations using bioprobes …

Metabolism and functions of phosphatidylserine

JE Vance, R Steenbergen - Progress in lipid research, 2005 - Elsevier
Phosphatidylserine (PS) is a quantitatively minor membrane phospholipid that is
synthesized by prokaryotic and eukaryotic cells. In this review we focus on genes and …

Structure and mode of action of clostridial glucosylating toxins: the ABCD model

T Jank, K Aktories - Trends in microbiology, 2008 - cell.com
Toxins A and B, which are the major virulence factors of antibiotic-associated diarrhea and
pseudomembranous colitis caused by Clostridium difficile, are the prototypes of the family of …

Toward a structural understanding of Clostridium difficile toxins A and B

RN Pruitt, DB Lacy - Frontiers in cellular and infection microbiology, 2012 - frontiersin.org
Clostridium difficile is a toxin-producing bacterium that is a frequent cause of hospital-
acquired and antibiotic-associated diarrhea. The incidence, severity, and costs associated …

Clostridial toxins

MR Popoff, P Bouvet - Future microbiology, 2009 - Taylor & Francis
Clostridia produce the highest number of toxins of any type of bacteria and are involved in
severe diseases in humans and other animals. Most of the clostridial toxins are pore-forming …

Structure of the full-length Clostridium difficile toxin B

P Chen, K Lam, Z Liu, FA Mindlin, B Chen… - Nature structural & …, 2019 - nature.com
Clostridium difficile is an opportunistic pathogen that establishes in the colon when the gut
microbiota are disrupted by antibiotics or disease. C. difficile infection (CDI) is largely …

Rho-glucosylating Clostridium difficile toxins A and B: new insights into structure and function

T Jank, T Giesemann, K Aktories - Glycobiology, 2007 - academic.oup.com
Clostridium difficile causes pseudomembranous colitis and is responsible for many cases of
nosocomial antibiotic-associated diarrhea. Major virulence factors of C. difficile are the …

Clostridium sordellii infection: epidemiology, clinical findings, and current perspectives on diagnosis and treatment

MJ Aldape, AE Bryant, DL Stevens - Clinical Infectious Diseases, 2006 - academic.oup.com
Clostridium sordellii infections pose difficult clinical challenges and are usually fatal. Most
commonly, these infections occur after trauma, childbirth, and routine gynecological …