The epithelial-mesenchymal transition (EMT) is a vital driver of tumor progression. It is a well-
known and complex trans-differentiation process in which epithelial cells undergo …

Metabolic reprogramming is an emerging hallmark of cancer and is driven by abnormalities
of oncogenes and tumor suppressors. Accelerated metabolism causes cancer cell …

Background Globally, colorectal cancer (CRC) affects more than 1 million people each year.
In addition to non-modifiable and other environmental risk factors, Fusobacterium nucleatum …

Vasculogenic Mimicry (VM) refers to the capacity to form a blood network from aggressive
cancer cells in an independent way of endothelial cells, to provide nutrients and oxygen …

Background and Aims Intestinal mucosa undergoes a continual process of proliferation,
differentiation, and apoptosis. Disruption of this homeostasis is associated with disorders …

The function and structure of the mammalian epithelial cell layer is maintained by distinct
intercellular adhesion complexes including adherens junctions (AJs), tight junctions, and …

Peroxisome proliferator-activated receptor α (PPARA) is a key mediator of lipid metabolism
and inflammation. Activation of PPARA in rodents causes hepatocyte proliferation, but the …

Enterotoxigenic Bacteroides fragilis (ETBF) has emerged as a gut microbiome pathogen that
can promote colitis associated cancer in humans. ETBF secretes the metalloprotease, B …

An early fundamental step in ovarian cancer progression is the dissemination of cancer cells
through liquid environments, one of them being cancer ascites accumulated in the …

The term moonlighting proteins refers to those proteins that present alternative functions
performed by a single polypeptide chain acquired throughout evolution (called canonical …