Cellular mechanisms of fibrin (ogen): insight from neurodegenerative diseases

T Wen, Z Zhang - Frontiers in Neuroscience, 2023 - frontiersin.org
Neurodegenerative diseases are prevalent and currently incurable conditions that
progressively impair cognitive, behavioral, and psychiatric functions of the central or …

Pathophysiological role of microglial activation induced by blood-borne proteins in Alzheimer's disease

S Kim, C Sharma, UJ Jung, SR Kim - Biomedicines, 2023 - mdpi.com
The blood–brain barrier (BBB) restricts entry of neurotoxic plasma components, blood cells,
and pathogens into the brain, leading to proper neuronal functioning. BBB impairment leads …

Fibrinogen, fibrinogen-like 1 and fibrinogen-like 2 proteins, and their effects

NH Sulimai, J Brown, D Lominadze - Biomedicines, 2022 - mdpi.com
Fibrinogen (Fg) and its derivatives play a considerable role in many diseases. For example,
increased levels of Fg have been found in many inflammatory diseases, such as Alzheimer's …

Vascular effects on cerebrovascular permeability and neurodegeneration

N Sulimai, J Brown, D Lominadze - Biomolecules, 2023 - mdpi.com
Neurons and glial cells in the brain are protected by the blood brain barrier (BBB). The local
regulation of blood flow is determined by neurons and signal conducting cells called …

The role of nuclear factor-kappa B in fibrinogen-induced inflammatory responses in cultured primary neurons

N Sulimai, J Brown, D Lominadze - Biomolecules, 2022 - mdpi.com
Traumatic brain injury (TBI) is an inflammatory disease associated with a compromised
blood–brain barrier (BBB) and neurodegeneration. One of the consequences of …

[HTML][HTML] Caffeic Acid Phenethyl Ester Protects Neurons Against Oxidative Stress and Neurodegeneration During Traumatic Brain Injury

N Sulimai, J Brown, D Lominadze - Biomolecules, 2025 - mdpi.com
Traumatic brain injury (TBI) is an inflammatory disease causing neurodegeneration. One of
the consequences of inflammation is an elevated blood level of fibrinogen (Fg). Earlier we …

Anti-GABAB receptor encephalitis: clinical and laboratory characteristics, imaging, treatments and prognosis

D Li, S Zong, Y Yao, PC Molenaar… - Frontiers in …, 2024 - frontiersin.org
Introduction Anti-GABABR encephalitis is a rare disease reported to be often associated with
tumors. The current study aims to summarize the clinical characteristics, imaging features …

Amyloid pathology mediates the associations between plasma fibrinogen and cognition in non‐demented adults

LY Ma, JH Song, PY Gao, YN Ou, Y Fu… - Journal of …, 2024 - Wiley Online Library
Though previous studies revealed the potential associations of elevated levels of plasma
fibrinogen with dementia, there is still limited understanding regarding the influence of …

The Effect of Reduced Fibrinogen on Cerebrovascular Permeability during Traumatic Brain Injury in Fibrinogen Gene Heterozygous Knockout Mice

N Sulimai, J Brown, D Lominadze - Biomolecules, 2024 - mdpi.com
Vascular contribution to cognitive impairment and dementia (VCID) is a term referring to all
types of cerebrovascular and cardiovascular disease-related cognitive decline, spanning …

Fibrinogen and hypertension are key factors associated with tremor relieve and recurrence in the ET patients subjected with MRgFUS thalamotomy

J Lin, H Lu, D Zhang, X Bian, J Hu, L Pan, X Lou - medRxiv, 2024 - medrxiv.org
Background There were variable differences and declines in efficacy of magnetic resonance
guided focused ultrasound (MRgFUS) thalamotomy, but whether the clinical status of these …