The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Obesity and type 2 diabetes mellitus are complicated metabolic diseases that affect multiple
organs and are characterized by hyperglycaemia. Currently, stable and effective treatments …

Exercise is an effective strategy for diabetes management but is limited by the phenomenon
of exercise resistance (ie, the lack of or the adverse response to exercise on metabolic …

Tirzepatide (LY3298176), a dual GIP and GLP-1 receptor (GLP-1R) agonist, delivered
superior glycemic control and weight loss compared with GLP-1R agonism in patients with …

Despite daily fasting and feeding, plasma glucose levels are normally maintained within a
narrow range owing to the hormones insulin and glucagon. Insulin increases glucose …

The association of obesity with type 2 diabetes has been recognized for decades, and the
major basis for this link is the ability of obesity to engender insulin resistance. Insulin …

The Mouse Metabolic Phenotyping Center (MMPC) Consortium was established to address
the need to characterize the growing number of mouse models of metabolic diseases …

To examine the mechanism by which free fatty acids (FFAs) induce insulin resistance in vivo,
awake chronically catheterized rats underwent a hyperinsulinemic-euglycemic clamp with or …

With the many recent advances in the biomedical world, vast changes are taking place in
our growing knowledge of the physiological aspects of almost all the tissues and organs of …

High levels of some but not all dietary fats lead to insulin resistance in rats. The aim of this
study was to investigate the important determinants underlying this observation. Insulin …