Opioids are used for pain management despite the side effects that contribute to the opioid
crisis. The pursuit of non-addictive opioid analgesics remains unattained due to the …

ABSTRACT Introduction Kratom (Mitragyna speciosa) has generated substantial clinical and
scientific interest as a complex natural product. Its predominant alkaloid mitragynine and …

Opioids are effective analgesics, but their use is beset by serious side effects, including
addiction and respiratory depression, which contribute to the ongoing opioid crisis. The …

The κ-opioid receptor (KOR) has emerged as an attractive drug target for pain management
without addiction, and biased signaling through particular pathways of KOR may be key to …

Trace-amine-associated receptors (TAARs), a group of biogenic amine receptors, have
essential roles in neurological and metabolic homeostasis. They recognize diverse …

GPR34 is a functional G-protein-coupled receptor of Lysophosphatidylserine (LysoPS), and
has pathogenic roles in numerous diseases, yet remains poorly targeted. We herein report a …

Summary Hydroxycarboxylic acid receptor 2 (HCAR2), modulated by endogenous ketone
body β-hydroxybutyrate and exogenous niacin, is a promising therapeutic target for …

G-protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by stimulating
guanine nucleotide exchange in the Gα subunit. To visualize this mechanism, we developed …

The US faces an unprecedented surge in fatal drug overdoses. Naloxone, the only antidote
for opiate overdose, competes at the mu opioid receptor (μOR) orthosteric site. Naloxone …

Drugs acting at the opioid receptor family are clinically used to treat chronic and acute pain,
though they represent the second line of treatment behind GABA analogs, antidepressants …